Role of Nitric Oxide-Detoxifying Enzymes in the Virulence of Pseudomonas aeruginosa against the Silkworm, Bombyx mori

被引：19

作者：

Arai, Hiroyuki ^{[1
]}

Iiyama, Kazuhiro ^{[2
]}

机构：

[1] Univ Tokyo, Dept Biotechnol, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Kyushu Univ, Fac Agr, Lab Insect Pathol & Microbial Control, Inst Biol Control,Grad Sch,Higashi Ku, Fukuoka 8128581, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 01期

基金：

日本学术振兴会;

关键词：

denitrification; nitric oxide reductase; flavohemoglobin; Pseudomonas aeruginosa; Bombyx mori; DENITRIFICATION; EXPRESSION; GENE; REDUCTASE; PAO1; INACTIVATION; MACROPHAGES; REGULATOR; SURVIVAL; SYNTHASE;

D O I：

10.1271/bbb.120656

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pseudomonas aeruginosa has two nitric oxide (NO)-detoxification enzymes, NO reductase and flavohemoglobin, which catalyze the reduction and oxygenation of NO respectively. In this study, the NO reductase-deficient mutant showed decreased virulence against the silkworm Bombyx mori, but the flavohemoglobin-deficient mutant did not, indicating that NO-reduction is important to the full virulence of P. aeruginosa against B. mori.

引用

页码：198 / 200

页数：3

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