Advances in celiac disease

被引:14
作者
Jones, RB [1 ]
Robins, GG [1 ]
Howdle, PD [1 ]
机构
[1] St James Univ Hosp, Acad Dept Med, Leeds LS9 7TF, W Yorkshire, England
关键词
celiac disease; gliadin epitopes; HLA-DQ2; proline; tissue transglutaminase;
D O I
10.1097/01.mog.0000208460.46395.9b
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Purpose of review This article primarily aims to review critically research in all aspects of celiac disease over the last year. As always, there has been a wealth of relevant papers. Recent findings The role of genetics in disease susceptibility is slowly becoming more clearly defined and a more detailed understanding of the disease processes at the molecular level is paving the way towards the development of specific targeted therapies. Summary Despite recent advances in our understanding of celiac disease, the gluten-free diet remains the only current viable therapy and even with advances in serological tests and markers, the duodenal biopsy remains the gold standard for diagnosis and monitoring of the response to therapy.
引用
收藏
页码:117 / 123
页数:7
相关论文
共 56 条
  • [1] Psychological support counselling improves gluten-free diet compliance in coeliac patients with affective disorders
    Addolorato, G
    De Lorenzi, G
    Abenavoli, L
    Leggio, L
    Capristo, E
    Gasbarrini, G
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 20 (07) : 777 - 782
  • [2] Genetic analysis of the CD28/CTLA4/ICOS (CELIAC3) region in coeliac disease
    Amundsen, SS
    Naluai, ÅT
    Ascher, H
    Ek, J
    Gudjónsdóttir, AH
    Wahlström, J
    Lie, BA
    Sollid, LM
    [J]. TISSUE ANTIGENS, 2004, 64 (05): : 593 - 599
  • [3] T cells in peripheral blood after gluten challenge in coeliac disease
    Anderson, RP
    van Heel, DA
    Tye-Din, JA
    Barnardo, M
    Salio, M
    Jewell, DP
    Hill, AVS
    [J]. GUT, 2005, 54 (09) : 1217 - 1223
  • [4] Celiac disease in an adult Turkish population with type 1 diabetes mellitus
    Aygun, C
    Uraz, S
    Damci, T
    Osar, Z
    Yumuk, V
    Akdenizli, E
    Ilkova, H
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2005, 50 (08) : 1462 - 1466
  • [5] Can tissue transglutaminase antibody titers replace small-bowel biopsy to diagnose celiac disease in select pediatric populations?
    Barker, CC
    Mitton, C
    Jevon, G
    Mock, T
    [J]. PEDIATRICS, 2005, 115 (05) : 1341 - 1346
  • [6] Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the Celiac disease-associated HLA-DQ2 molecule
    Bergseng, E
    Xia, J
    Kim, CY
    Khosla, C
    Sollid, LM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) : 21791 - 21796
  • [7] Factors relating to compliance with a gluten-free diet in patients with coeliac disease: comparison of white Caucasian and South Asian patients
    Butterworth, JR
    Banfield, LM
    Iqbal, TH
    Cooper, BT
    [J]. CLINICAL NUTRITION, 2004, 23 (05) : 1127 - 1134
  • [8] Direct visualization of intestinal villi by high-resolution magnifying upper endoscopy:: a validation study
    Cammarota, G
    Martino, A
    Pirozzi, GA
    Cianci, R
    Cremonini, F
    Zuccalà, G
    Cuoco, L
    Ojetti, V
    Montalto, M
    Vecchio, FM
    Gasbarrini, A
    Gasbarrini, G
    [J]. GASTROINTESTINAL ENDOSCOPY, 2004, 60 (05) : 732 - 738
  • [9] Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study
    Card, TR
    West, J
    Holmes, GKT
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 20 (07) : 769 - 775
  • [10] Anti-actin antibodies in celiac disease: Correlation with intestinal mucosa damage and comparison of ELISA with the immunofluorescence assay
    Carroccio, A
    Brusca, I
    Iacono, G
    Di Prima, L
    Teresi, S
    Pirrone, G
    Florena, AM
    La Chinsa, SM
    Averna, MR
    [J]. CLINICAL CHEMISTRY, 2005, 51 (05) : 917 - 920