Cytochrome P450 2C19 genotyping for clopidogrel response - the state of play

被引:1
作者
Dick, R. J. [1 ]
Byron, K. A. [3 ]
Dear, A. E. [2 ]
机构
[1] Monash Univ, Epworth Hosp, Dept Cardiol, Melbourne, Vic 3004, Australia
[2] Monash Univ, Australian Ctr Blood Dis, Dept Med, Melbourne, Vic 3004, Australia
[3] Monash Univ, HealthScope Adv Pathol, Melbourne, Vic 3004, Australia
关键词
OF-FUNCTION POLYMORPHISM; ACUTE CORONARY SYNDROMES; CYP2C19; GENOTYPE; CARDIOVASCULAR EVENTS; STENT THROMBOSIS; METAANALYSIS; OUTCOMES; RESPONSIVENESS; VARIABILITY;
D O I
10.1111/j.1445-5994.2012.02896.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:7 / 8
页数:2
相关论文
共 18 条
[1]   Variability in individual responsiveness to clopidogrel - Clinical implications, management, and future perspectives [J].
Angiolillo, Dominick J. ;
Fernandez-Ortiz, Antonio ;
Bernardo, Esther ;
Alfonso, Fernando ;
Macaya, Carlos ;
Bass, Theodore A. ;
Costa, Marco A. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (14) :1505-1516
[2]   Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis [J].
Bauer, Tim ;
Bouman, Heleen J. ;
van Werkum, Jochem W. ;
Ford, Neville F. ;
ten Berg, Jurrien M. ;
Taubert, Dirk .
BMJ-BRITISH MEDICAL JOURNAL, 2011, 343
[3]   Clinical, Angiographic, and Genetic Factors Associated With Early Coronary Stent Thrombosis [J].
Cayla, Guillaume ;
Hulot, Jean-Sebastien ;
O'Connor, Stephen A. ;
Pathak, Atul ;
Scott, Stuart A. ;
Gruel, Yves ;
Silvain, Johanne ;
Vignalou, Jean-Baptiste ;
Huerre, Yves ;
de la Briolle, Axel ;
Allanic, Frederick ;
Beygui, Farzin ;
Barthelemy, Olivier ;
Montalescot, Gilles ;
Collet, Jean-Philippe .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (16) :1765-1774
[4]   Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study [J].
Collet, Jean-Philippe ;
Hulot, Jean-Sebastien ;
Pena, Anna ;
Villard, Eric ;
Esteve, Jean-Baptiste ;
Silvain, Johanne ;
Payot, Laurent ;
Brugier, Delphine ;
Cayla, Guillaume ;
Beygui, Farzin ;
Bensimon, Gilbert ;
Funck-Brentano, Christian ;
Montalescot, Gilles .
LANCET, 2009, 373 (9660) :309-317
[5]   P2Y12 platelet inhibition in clinical practice [J].
Damman, Peter ;
Woudstra, Pier ;
Kuijt, Wichert J. ;
de Winter, Robbert J. ;
James, Stefan K. .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2012, 33 (02) :143-153
[6]   Clopidogrel response variability: Current status and future directions [J].
Ferreiro, Jose Luis ;
Angiolillo, Dominick J. .
THROMBOSIS AND HAEMOSTASIS, 2009, 102 (01) :7-14
[7]   CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events A Systematic Review and Meta-analysis [J].
Holmes, Michael V. ;
Perel, Pablo ;
Shah, Tina ;
Hingorani, Aroon D. ;
Casas, Juan P. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 306 (24) :2704-2714
[8]   Cytochrorne P4502C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects [J].
Hulot, Jean-Sebastien ;
Bura, Alessandra ;
Villard, Eric ;
Azizi, Michel ;
Remones, Veronique ;
Goyenvalle, Catherine ;
Aiach, Martine ;
Lechat, Philippe ;
Gaussem, Pascale .
BLOOD, 2006, 108 (07) :2244-2247
[9]   Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI A Meta-analysis [J].
Mega, Jessica L. ;
Simon, Tabassome ;
Collet, Jean-Philippe ;
Anderson, Jeffrey L. ;
Antman, Elliott M. ;
Bliden, Kevin ;
Cannon, Christopher P. ;
Danchin, Nicolas ;
Giusti, Betti ;
Gurbel, Paul ;
Horne, Benjamin D. ;
Hulot, Jean-Sebastian ;
Kastrati, Adnan ;
Montalescot, Gilles ;
Neumann, Franz-Josef ;
Shen, Lei ;
Sibbing, Dirk ;
Steg, P. Gabriel ;
Trenk, Dietmar ;
Wiviott, Stephen D. ;
Sabatine, Marc S. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (16) :1821-1830
[10]   Cytochrome P-450 Polymorphisms and Response to Clopidogrel. [J].
Mega, Jessica L. ;
Close, Sandra L. ;
Wiviott, Stephen D. ;
Shen, Lei ;
Hockett, Richard D. ;
Brandt, John T. ;
Walker, Joseph R. ;
Antman, Elliott M. ;
Macias, William ;
Braunwald, Eugene ;
Sabatine, Marc S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (04) :354-362