Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

被引：788

作者：

Miyata, M ^{[1
]}

Smith, JD ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,BIOCHEM GENET & METAB LAB,NEW YORK,NY 10021

来源：

NATURE GENETICS | 1996年 / 14卷 / 01期

关键词：

D O I：

10.1038/ng0996-55

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity. To probe the mechanism of these associations, cell lines were created which secrete each apoE isoform. ApoE conditioned media, purified apoE, and commercially obtained apoE protected B12 cells from hydrogen peroxide cytotoxicity with E2 > E3 > E4. Physiological levels of apoE protected cells from P-amyloid peptides, while higher doses of apoE led to increased cytotoxicity. E2 > E3 > E4 possessed antioxidant activity, and apoE bound certain metal ions. The decreased antioxidant activity of E4 could contribute to its association with Alzheimer's disease, cardiovascular disease and decreased longevity.

引用

页码：55 / 61

页数：7

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