Medial temporal lobe structures participate differentially in consolidation of safe and aversive taste memories

被引：33

作者：

De la Cruz, Vanesa ^{[1
]}

Rodriguez-Ortiz, Carlos J. ^{[1
]}

Balderas, Israela ^{[1
]}

Bermudez-Rattoni, Federico ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Dept Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 07期

关键词：

amygdala; anisomycin; attenuation of neophobia; conditioned taste aversion; hippocampus; perirhinal cortex;

D O I：

10.1111/j.1460-9568.2008.06432.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Taste memories are amongst the most important kinds of memories, as adequate identification of safe and toxic edibles will determine the subject's survival. Despite the well-established role that the medial temporal lobe plays in consolidation of memory, specific contributions of the different regions of the temporal lobe to taste memory consolidation remain unknown. In the present report, we assessed the participation of perirhinal cortex (Ph), dorsal hippocampus (Hipp), basolateral (BLA) and central nuclei of the amygdala (CeA) in safe and aversive taste memories by means of local infusions of the protein synthesis inhibitor anisomycin in the rat. The results showed that protein synthesis in the CeA, but not BLA, is required to stabilize taste aversion memory. Surprisingly, the Ph and Hipp seem to be essential to consolidate safe taste memory. These data suggest that different networks within the temporal lobe are recruited to consolidate memory depending on the consequences associated with tastes.

引用

页码：1377 / 1381

页数：5

共 39 条

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