Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

被引：22

作者：

Lee, Yoonyeong ^{[2
]}

Jang, Kyoung Hwa ^{[2
]}

Jeon, Ju-eun ^{[2
]}

Yang, Woo-Young ^{[1
]}

Sim, Chung J. ^{[3
]}

Oh, Ki-Bong ^{[1
]}

Shin, Jongheon ^{[2
]}

机构：

[1] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 151921, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

[3] Hannam Univ, Coll Life Sci & Nanotechnol, Dept Biol Sci, Taejon 305811, South Korea

来源：

MARINE DRUGS | 2012年 / 10卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Haliclona sp; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity; MARINE SPONGE; CYCLOSTELLETTAMINE-K; HISTONE DEACETYLASE; ALKALOIDS; GROWTH; INHIBITORS; ASSAY;

D O I：

10.3390/md10092126

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

引用

页码：2126 / 2137

页数：12

共 50 条

[41] Neuromodulatory Steroid Metabolites From the Sponge Topsentia sp. [J].

Cai, Lijuan ;

Zhou, Luyu ;

Xi, Chuchu ;

Ren, Kerui ;

Cheng, Zezhong ;

Cao, Zhengyu ;

Han, Hua ;

Zhang, Wen .

CHEMISTRY & BIODIVERSITY, 2025,

[42] New Indole Alkaloids from the Sponge Plakortis sp. [J].

Hanif, Novriyandi ;

Yamada, Kaoru ;

Kitamura, Makoto ;

Kawazoe, Yoshinori ;

de Voogd, Nicole J. ;

Uemura, Daisuke .

CHEMISTRY OF NATURAL COMPOUNDS, 2015, 51 (06) :1130-1133

[43] Triterpene Galactosides of the Pouoside Class and Corresponding Aglycones from the Sponge Lipastrotethya sp. [J].

Lee, Jung-Ho ;

Jang, Kyoung Hwa ;

Lee, Yeon-Ju ;

Lee, Hyi-Seung ;

Sim, Chung J. ;

Oh, Ki-Bong ;

Shin, Jongheon .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (12) :2563-2570

[44] A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp and its cytotoxic activity [J].

Zhang, Huawei ;

Loveridge, Steven T. ;

Tenney, Karen ;

Crews, Phillip .

NATURAL PRODUCT RESEARCH, 2016, 30 (11) :1262-1265

[45] Aciculitin D, a cytotoxic heterodetic cyclic peptide from a Poecillastra sp. marine sponge [J].

Sugawara, Kenji ;

Kanki, Daichi ;

Watanabe, Ryuichi ;

Matsushima, Ryoji ;

Ise, Yuji ;

Yokose, Hisayoshi ;

Morii, Yasuhiro ;

Yamawaki, Nobuhiro ;

Ninomiya, Akihiro ;

Okada, Shigeru ;

Matsunaga, Shigeki .

TETRAHEDRON, 2022, 119

[46] STYLISSAMIDE I, A NEW CYCLIC HEPTAPEPTIDE FROM AN OKINAWAN MARINE SPONGE STYLISSA sp. [J].

Kubota, Takaaki ;

Nakamura, Kenta ;

Kurimoto, Shin-ichiro ;

Sakai, Kanae ;

Fromont, Jane ;

Gonoi, Tohru ;

Kobayashi, Jun'ichi .

HETEROCYCLES, 2017, 95 (02) :799-806

[47] Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge Psammocinia sp. [J].

El-Desoky, Ahmed H. H. ;

Hitora, Yuki ;

Onodera, Keita ;

Ise, Yuji ;

Losung, Fitje ;

Mangindaan, Remy E. P. ;

Tsukamoto, Sachiko .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2022, 70 (11) :818-822

[48] A New Cytotoxic Polyacetylenic Alcohol from a Sponge Callyspongia sp. [J].

Balansa, Walter ;

Trianto, Agus ;

de Voogd, Nicole J. ;

Tanaka, Junichi .

NATURAL PRODUCT COMMUNICATIONS, 2017, 12 (12) :1909-1911

[49] 5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp. [J].

Su, Tzu-Rong ;

Liang, Kai-Ju ;

Chiang, Michael Y. ;

Lu, Mei-Chin ;

Wu, Yu-Jen ;

Su, Jui-Hsin .

NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (11) :1535-1536

[50] New Bioactive Polyacetylenes from the Marine Sponge Petrosia sp. [J].

Liu, Xin-Lian ;

Ding, Ya-Fang ;

Wang, Shu-Ping ;

Liu, Li ;

Wang, Jie ;

Yang, Fan .

CHEMISTRY & BIODIVERSITY, 2022, 19 (06)

← 1 2 3 4 5 →