Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

被引：22

作者：

Lee, Yoonyeong ^{[2
]}

Jang, Kyoung Hwa ^{[2
]}

Jeon, Ju-eun ^{[2
]}

Yang, Woo-Young ^{[1
]}

Sim, Chung J. ^{[3
]}

Oh, Ki-Bong ^{[1
]}

Shin, Jongheon ^{[2
]}

机构：

[1] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 151921, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

[3] Hannam Univ, Coll Life Sci & Nanotechnol, Dept Biol Sci, Taejon 305811, South Korea

来源：

MARINE DRUGS | 2012年 / 10卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Haliclona sp; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity; MARINE SPONGE; CYCLOSTELLETTAMINE-K; HISTONE DEACETYLASE; ALKALOIDS; GROWTH; INHIBITORS; ASSAY;

D O I：

10.3390/md10092126

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

引用

页码：2126 / 2137

页数：12

共 50 条

[21] Biological Characterisation of Haliclona (?gellius) sp.: Sponge and Associated Microorganisms [J].

Sipkema, Detmer ;

Holmes, Bradley ;

Nichols, Scott A. ;

Blanch, Harvey W. .

MICROBIAL ECOLOGY, 2009, 58 (04) :903-920

[22] 2-Palmitamidoethanesulfonic acid, a taurine derivative from the marine sponge Haliclona sp. [J].

Bin Wang ;

Kyung Jin Lee ;

Si Zhang ;

Jee H. Jung ;

Yonghong Liu .

Chemistry of Natural Compounds, 2009, 45 :137-138

[23] Antifungal and antibacterial activity of Haliclona sp. from the Persian Gulf, Iran [J].

Nazemi, M. ;

Salimi, M. Alidoust ;

Salimi, P. Alidoust ;

Motallebi, A. ;

Jahromi, S. Tamadoni ;

Ahmadzadeh, O. .

JOURNAL DE MYCOLOGIE MEDICALE, 2014, 24 (03) :220-224

[24] Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp. [J].

Maarisit, Wilmar ;

Abdjul, Delfly B. ;

Yamazaki, Hiroyuki ;

Kato, Hajime ;

Rotinsulu, Henki ;

Wewengkang, Defny S. ;

Sumilat, Deiske A. ;

Kapojos, Magie M. ;

Ukai, Kazuyo ;

Namikoshi, Michio .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (15) :3503-3506

[25] Diversity of bacteria and polyketide synthase associated with marine sponge Haliclona sp. [J].

Shams Tabrez Khan ;

Javed Musarrat ;

Abdulaziz A. Alkhedhairy ;

Shinya Kazuo .

Annals of Microbiology, 2014, 64 :199-207

[26] Scalarane Sesterterpenes from the Sponge Hyatella sp. [J].

Jeon, Ju-eun ;

Bae, Jaemin ;

Lee, Kyung Jin ;

Oh, Ki-Bong ;

Shin, Jongheon .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (04) :847-851

[27] Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp. [J].

Campos, Pierre-Eric ;

Herbette, Gaetan ;

Chendo, Christophe ;

Clerc, Patricia ;

Tintillier, Florent ;

de Voogd, Nicole J. ;

Papanagnou, Eleni-Dimitra ;

Trougakos, Ioannis P. ;

Jerabek, Moran ;

Bignon, Jerome ;

Le Goff, Geraldine ;

Ouazzani, Jamal ;

Gauvin-Bialecki, Anne .

MARINE DRUGS, 2020, 18 (07)

[28] Structure determination of two new compounds isolated from a marine sponge Haliclona(Gellius) sp. [J].

Lee, Kyung ;

Kim, Yun Na ;

Jeong, Eun Ju .

JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY, 2021, 25 (02) :24-32

[29] Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine [J].

Kim, Yun Na ;

Ji, Yeong Kwang ;

Kim, Na-Hyun ;

Van Tu, Nguyen ;

Rho, Jung-Rae ;

Jeong, Eun Ju .

MARINE DRUGS, 2021, 19 (02)

[30] Antimicrobial activity and cytotoxicity of bis(indole) alkaloids from the sponge Spongosorites sp. [J].

Oh, KB ;

Mar, W ;

Kim, S ;

Kim, JY ;

Lee, TH ;

Kim, JG ;

Shin, D ;

Sim, CJ ;

Shin, J .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (03) :570-573

← 1 2 3 4 5 →