Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

被引：20

作者：

Lee, Yoonyeong ^{[2
]}

Jang, Kyoung Hwa ^{[2
]}

Jeon, Ju-eun ^{[2
]}

Yang, Woo-Young ^{[1
]}

Sim, Chung J. ^{[3
]}

Oh, Ki-Bong ^{[1
]}

Shin, Jongheon ^{[2
]}

机构：

[1] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, Seoul 151921, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

[3] Hannam Univ, Coll Life Sci & Nanotechnol, Dept Biol Sci, Taejon 305811, South Korea

来源：

MARINE DRUGS | 2012年 / 10卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Haliclona sp; bis-1,3-dialkylpyridiniums; cyclostellettamines; cytotoxicity; antimicrobial activity; MARINE SPONGE; CYCLOSTELLETTAMINE-K; HISTONE DEACETYLASE; ALKALOIDS; GROWTH; INHIBITORS; ASSAY;

D O I：

10.3390/md10092126

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

引用

页码：2126 / 2137

页数：12

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