Exercise and the Gut Microbiome: A Review of the Evidence, Potential Mechanisms, and Implications for Human Health

被引:345
作者
Mailing, Lucy J. [1 ]
Allen, Jacob M. [2 ]
Buford, Thomas W. [3 ]
Fields, Christopher J. [4 ]
Woods, Jeffrey A. [1 ,5 ]
机构
[1] Univ Illinois, Div Nutr Sci, Champaign, IL USA
[2] Nationwide Childrens Hosp, Ctr Microbial Pathogenesis, Columbus, OH USA
[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
[4] Univ Illinois, Carver Biotechnol Ctr, High Performance Comp Biol, Champaign, IL USA
[5] Univ Illinois, Dept Kinesiol & Community Hlth, Champaign, IL USA
来源
EXERCISE AND SPORT SCIENCES REVIEWS | 2019年 / 47卷 / 02期
基金
美国国家卫生研究院;
关键词
endurance exercise; gut microbiota; short-chain fatty acids; butyrate; gut health; inflammatory bowel disease; QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; SODIUM-BUTYRATE; CARDIORESPIRATORY FITNESS; INTESTINAL MICROBIOTA; BRAIN AXIS; BILE-ACID; VOLUNTARY; METABOLISM; INCREASES;
D O I
10.1249/JES.0000000000000183
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The gastrointestinal tract contains trillions of microbes (collectively known as the gut microbiota) that play essential roles in host physiology and health. Studies from our group and others have demonstrated that exercise independently alters the composition and functional capacity of the gutmicrobiota. Here, we review what is known about the gut microbiota, how it is studied, and how it is influenced by exercise training and discuss the potential mechanisms and implications for human health and disease.
引用
收藏
页码:75 / 85
页数:11
相关论文
共 113 条
[1]   Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome [J].
Abubucker, Sahar ;
Segata, Nicola ;
Goll, Johannes ;
Schubert, Alyxandria M. ;
Izard, Jacques ;
Cantarel, Brandi L. ;
Rodriguez-Mueller, Beltran ;
Zucker, Jeremy ;
Thiagarajan, Mathangi ;
Henrissat, Bernard ;
White, Owen ;
Kelley, Scott T. ;
Methe, Barbara ;
Schloss, Patrick D. ;
Gevers, Dirk ;
Mitreva, Makedonka ;
Huttenhower, Curtis .
PLOS COMPUTATIONAL BIOLOGY, 2012, 8 (06)
[2]   Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice [J].
Allen, J. M. ;
Mailing, L. J. ;
Cohrs, J. ;
Salmonson, C. ;
Fryer, J. D. ;
Nehra, V. ;
Hale, V. L. ;
Kashyap, P. ;
White, B. A. ;
Woods, J. A. .
GUT MICROBES, 2018, 9 (02) :115-130
[3]  
Allen JM, 2018, MED SCI SPORT EXER, V50, P747, DOI [10.1249/MSS.0000000000001495, 10.1249/mss.0000000000001495]
[4]   Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice [J].
Allen, Jacob M. ;
Miller, Margret E. Berg ;
Pence, Brandt D. ;
Whitlock, Keith ;
Nehra, Vandana ;
Gaskins, H. Rex ;
White, Bryan A. ;
Fryer, John D. ;
Woods, Jeffrey A. .
JOURNAL OF APPLIED PHYSIOLOGY, 2015, 118 (08) :1059-1066
[5]  
Anderson MJ, 2003, ECOLOGY, V84, P511, DOI 10.1890/0012-9658(2003)084[0511:CAOPCA]2.0.CO
[6]  
2
[7]  
ANDRIANOPOULOS G, 1987, ANTICANCER RES, V7, P849
[8]   Activities at the Universal Protein Resource (UniProt) [J].
Apweiler, Rolf ;
Bateman, Alex ;
Martin, Maria Jesus ;
O'Donovan, Claire ;
Magrane, Michele ;
Alam-Faruque, Yasmin ;
Alpi, Emanuele ;
Antunes, Ricardo ;
Arganiska, Joanna ;
Casanova, Elisabet Barrera ;
Bely, Benoit ;
Bingley, Mark ;
Bonilla, Carlos ;
Britto, Ramona ;
Bursteinas, Borisas ;
Chan, Wei Mun ;
Chavali, Gayatri ;
Cibrian-Uhalte, Elena ;
Da Silva, Alan ;
De Giorgi, Maurizio ;
Dogan, Tunca ;
Fazzini, Francesco ;
Gane, Paul ;
Castro, Leyla Garcia ;
Garmiri, Penelope ;
Hatton-Ellis, Emma ;
Hieta, Reija ;
Huntley, Rachael ;
Legge, Duncan ;
Liu, Wudong ;
Luo, Jie ;
MacDougall, Alistair ;
Mutowo, Prudence ;
Nightingale, Andrew ;
Orchard, Sandra ;
Pichler, Klemens ;
Poggioli, Diego ;
Pundir, Sangya ;
Pureza, Luis ;
Qi, Guoying ;
Rosanoff, Steven ;
Saidi, Rabie ;
Sawford, Tony ;
Shypitsyna, Aleksandra ;
Turner, Edward ;
Volynkin, Vladimir ;
Wardell, Tony ;
Watkins, Xavier ;
Zellner, Hermann ;
Corbett, Matt .
NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) :D191-D198
[9]   The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level [J].
Barton, Wiley ;
Penney, Nicholas C. ;
Cronin, Owen ;
Garcia-Perez, Isabel ;
Molloy, Michael G. ;
Holmes, Elaine ;
Shanahan, Fergus ;
Cotter, Paul D. ;
O'Sullivan, Orla .
GUT, 2018, 67 (04) :625-633
[10]   Intestinal tumours, colonic butyrate and sleep in exercised Min mice [J].
Basterfield, Laura ;
Mathers, John C. .
BRITISH JOURNAL OF NUTRITION, 2010, 104 (03) :355-363