Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension

被引：6

作者：

Fang, Jinrui ^{[1
]}

Ma, Liya ^{[1
]}

Zhang, Shuhong ^{[2
]}

Fang, Yan ^{[1
]}

Su, Peng ^{[1
]}

Ma, Huiyuan ^{[1
]}

机构：

[1] Peoples Hosp Gansu Prov, Dept Cardiol, Ward Cadre 3, Lanzhou 730000, Gansu, Peoples R China

[2] Womens Secondary Sch Gansu Prov, Lanzhou 730000, Gansu, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2013年 / 7卷 / 01期

关键词：

essential hypertension; gene polymorphism; myeloperoxidase; genetic susceptibility; carotid artery ultrasound; atherosclerosis; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA THICKNESS; CHRONIC HEART-FAILURE; CANCER RISK; POLYMORPHISMS; PROGRESSION; PATHOGENESIS; INFLAMMATION; POPULATION; PLAQUE;

D O I：

10.3892/mmr.2012.1143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to investigate the association between myeloperoxidase (MPO) gene polymorphisms and carotid atherosclerosis (AS) in patients with essential hypertension (EH). A total of 214 patients with EH were divided into an AS and a non-atherosclerosis (non-AS) group. MPO gene polymorphisms in EH were detected using PCR. The frequency of increased intima-media thickness and the occurrence of plaque in the carotid artery in the AS group was higher compared to the non-AS group. The frequency of the GC genotype in the AS group was significantly higher compared to the non-AS group. The frequency of carotid AS is higher in patients with hypertension, which is related to the MPO gene polymorphism.

引用

页码：313 / 317

页数：5

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