Cognitive impairment in three subtypes of multiple sclerosis

被引:120
作者
Denney, DR
Sworowski, LA
Lynch, SG
机构
[1] Univ Kansas, Dept Psychol, Lawrence, KS 66045 USA
[2] Univ Kansas, Med Ctr, Lawrence, KS 66045 USA
关键词
multiple sclerosis; cognition; neuropsychology; depression;
D O I
10.1016/j.acn.2005.04.012
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Patients with relapsing, primary progressive, and secondary progressive MS were administered the Tower of London and the Stroop, Color-Word Interference Test, yielding several measures of executive function and speeded information processing. MS patients' performance was compared with healthy controls and with a clinical control group consisting of patients with rheumatoid arthritis. The MS patients performed the tests more slowly, but did not differ from either group of controls on measures of executive function. Slowing in the speed of information processing was characteristic of MS patients across two basic tasks differing in terms of controlled versus automatic processing and in terms of whether or not rapid responding was an explicit feature of successful performance. Although evident in all subtypes, this slowing was more pronounced in secondary progressive patients and somewhat less pronounced in primary progressive patients. Furthermore, the slowing was unrelated to patients' disability status or level of depression. (c) 2005 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:967 / 981
页数:15
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