Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC

被引：0
|
作者：
Yue, Yanping [1 ]
Wu, Yumeng [2 ]
Zhao, Dakun [1 ]
Wu, Biao [1 ]
Wu, Xuming [3 ]
Liu, Jibin [2 ]
Yang, Lei [4 ]
Shen, Aiguo [2 ]
机构：
[1] Nantong Univ, Nantong, Jiangsu, Peoples R China
[2] Nantong Univ, Canc Res Ctr Nantong, Affiliated Tumor Hosp, Nantong, Jiangsu, Peoples R China
[3] Nantong Fourth Peoples Hosp, Nantong, Jiangsu, Peoples R China
[4] Nantong Univ, Dept Oncol, Affiliated Tumor Hosp, Nantong, Jiangsu, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2022年 / 2022卷
关键词：
RENAL-CELL CARCINOMA; IDENTIFICATION; INFLAMMATION; ACTIVATION; PSORIASIS; MODEL;
D O I：
10.1155/2022/4541571
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell carcinoma (ccRCC) across 33 cancers. With the help of patient transcription and clinical data from the TCGA and GEO (GSE53757, GSE36895) databases, we determined that in the immune environment of patients with ccRCC, ZC3H12C was clearly negatively correlated with Tregs and was significantly positively correlated with monocytes. In addition, protein phosphorylation and DNA methylation analysis also showed that ZC3H12C negatively regulates the role of cancer in ccRCC. Our research may provide new insights into ccRCC immunotherapy and bring forth novel biomarkers and therapeutic targets.
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页数：19
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