FOXP3-specific immunity

被引：8

作者：

Andersen, Mads Hald ^{[1
]}

机构：

[1] Copenhagen Univ Hosp, Dept Hematol, CCIT, Herlev, Denmark

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 10期

关键词：

foxp3; CTL; antigen; Tregs; HLA class I restricted T-cell epitope;

D O I：

10.4161/onci.26247

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forkhead box P3 (FOXP3)-specific cytotoxic CD8(+) T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3(+) malignant T cells. The natural occurrence of FOXP3-specific cytotoxic T lymphocytes among human PBMCs suggests a general role for these cells in the complex network of immune regulation.

引用

页数：3

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