FOXP3-specific immunity

被引：7
作者：
Andersen, Mads Hald [1 ]
机构：
[1] Copenhagen Univ Hosp, Dept Hematol, CCIT, Herlev, Denmark
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 10期
关键词：
foxp3; CTL; antigen; Tregs; HLA class I restricted T-cell epitope;
D O I：
10.4161/onci.26247
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Forkhead box P3 (FOXP3)-specific cytotoxic CD8(+) T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3(+) malignant T cells. The natural occurrence of FOXP3-specific cytotoxic T lymphocytes among human PBMCs suggests a general role for these cells in the complex network of immune regulation.
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