Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis

被引：21
作者：
Ovejero-Benito, Maria C. [1 ]
Prieto-Perez, Rocio [1 ]
Llamas-Velasco, Mar [2 ]
Munoz-Aceituno, Ester [2 ]
Reolid, Alejandra [2 ]
Saiz-Rodriguez, Miriam [1 ]
Belmonte, Carmen [1 ]
Roman, Manuel [1 ,3 ]
Ochoa, Dolores [1 ,3 ]
Talegon, Maria [1 ]
Cabaleiro, Teresa [1 ]
Dauden, Esteban [2 ]
Abad-Santos, Francisco [1 ,3 ,4 ]
机构：
[1] Univ Autonoma Madrid, Hosp Univ Princesa, Dept Clin Pharmacol, Inst Teofilo Hernando,Inst Invest Sanitaria Princ, E-28006 Madrid, Spain
[2] Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Dept Dermatol, E-28006 Madrid, Spain
[3] Hosp Princesa, UICEC, SCReN Spanish Clin Res Network, Serv Farmacol Clin, E-28006 Madrid, Spain
[4] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, E-28029 Madrid, Spain
来源：
PHARMACOGENOMICS | 2018年 / 19卷 / 01期
关键词：
adalimumab; anti-TNF drugs; infliximab; pharmacogenetics; psoriasis; ANTI-TNF THERAPY; GENOME-WIDE ASSOCIATION; GENE POLYMORPHISMS; RHEUMATOID-ARTHRITIS; CLINICAL-RESPONSE; PREDICT RESPONSE; ALPHA-BLOCKERS; DOUBLE-BLIND; HLA-C; SUSCEPTIBILITY;
D O I：
10.2217/pgs-2017-0143
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab. Materials & methods: Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patients with moderate-to-severe plaque psoriasis at 3 months (n = 95) and 6 months of treatment (n = 90). Significant SNPs for univariate analysis were subjected to multivariate analysis. Results: Five SNPs were associated with PASI75 at 3 months: rs6661932 (IVL), rs2546890 (IL-12B), rs2145623 (NFKBIA), rs9304742 (ZNF816A) and rs645544 (SLC9A8). Furthermore, rs1061624 (TNFR1B) was associated with PASI75 at 6 months. Conclusion: Nevertheless, these biomarkers should be validated in large-scale studies before implementation in clinical practice.
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收藏
页码：7 / 16
页数：10
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