TBAF-Catalyzed synthesis of 5-substituted IH-tetrazoles under solventless conditions

被引：283

作者：

Amantini, D ^{[1
]}

Beleggia, R ^{[1
]}

Fringuelli, F ^{[1
]}

Pizzo, F ^{[1
]}

Vaccaro, L ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim, Chim Organ Lab,CEMIN, Ctr Eccelenza Mat Innovat Applicaz Chim Fis & Bio, I-06123 Perugia, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 08期

关键词：

D O I：

10.1021/jo0499468

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrabutylammonium fluoride (TBAF) is an efficient catalyst in the [3 + 2] cycloaddition reaction of organic nitriles 1 with trimethylsilyl azide (TMSN3) in solventless conditions. The corresponding 5-substituted 1H-tetrazoles 2 were obtained under mild conditions and in 80-97% yields.

引用

页码：2896 / 2898

页数：3

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