Neuroblastoma and MYCN

被引：462
作者：
Huang, Miller
Weiss, William A. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2013年 / 3卷 / 10期
基金：
美国国家卫生研究院;
关键词：
HUMAN N-MYC; DIRECT TRANSCRIPTIONAL TARGET; C-MYC; TUMOR-SUPPRESSOR; UP-REGULATION; NEURONAL DIFFERENTIATION; ACTIVATING MUTATIONS; THERAPEUTIC TARGET; DOWN-REGULATION; CELL-CYCLE;
D O I：
10.1101/cshperspect.a014415
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in similar to 25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
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页数：22
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