Immunotherapy for advanced thyroid cancers - rationale, current advances and future strategies

被引：50

作者：

French, Jena D. ^{[1
,2
]}

机构：

[1] Univ Colorado Denver, Dept Med, Div Endocrinol Metab & Diabet, Denver, CO 80204 USA

[2] Univ Colorado Denver, Ctr Canc, Aurora, CO USA

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2020年 / 16卷 / 11期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; T-CELL RECOGNITION; ASSOCIATION GUIDELINES; ANTIGEN PRESENTATION; SERUM THYROGLOBULIN; PREDICTS RESPONSE; SUPPRESSOR-CELLS; NEXT-GENERATION; IMMUNE-RESPONSE; BRAF INHIBITOR;

D O I：

10.1038/s41574-020-0398-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With immune checkpoint blockade (ICB) technologies increasingly being used in cancer immunotherapy, early data suggest that ICB therapies could be effective in thyroid cancer. This Review discusses our current knowledge of the immune response in thyroid cancers, the latest and ongoing immune-based approaches and the future of immunotherapies in thyroid cancer. In the past decade, the field of cancer immunotherapy has been revolutionized by immune checkpoint blockade (ICB) technologies. Success across a broad spectrum of cancers has led to a paradigm shift in therapy for patients with advanced cancer. Early data are now accumulating in progressive thyroid cancers treated with single-agent ICB therapies and combination approaches that incorporate ICB technologies. This Review discusses our current knowledge of the immune response in thyroid cancers, the latest and ongoing immune-based approaches, and the future of immunotherapies in thyroid cancer. Physiologically relevant preclinical mouse models and human correlative research studies will inform development of the next stage of immune-based therapies for patients with advanced thyroid cancer.

引用

页码：629 / 641

页数：13

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