ANTI-OBESITY ACTIVITY OF EXTRACT UNDER VARIOUS FRACTIONS OF JAMBU AIR SAMARANG (SYZYGIUM SAMARANGENSE) LEAVES ON WISTAR FEMALE RATS

Syzygium samarangense was the lipase inhibitor that capable of inhibiting lipid absorption, so it assumes have a potency to be anti-obesity agent. The purpose of this study was to evaluate the anti-obesity effect of extract and various fractions of Syzygium samarangense leaves. The extracts were prepared by maceration method while fractionation process was carried out using liquid-liquid extraction method. This study was also done using Wistar female rats induced by high carbohydrate food for 45 days and Monosodium Glutamate (MSG) subcutaneous injection 2 g/kg body weight of rat for 5 consecutive days followed by 14 days treatment. Induction with high carbohydrate food was continued during the treatment time. Results showed that MSG and high carbohydrate food could induce obesity. The extract (containing n-hexane and ethyl acetate fraction) at a dose of 50 mg/kg body weight of rat had anti-obesity effect by inhibiting body weight. The best activity was shown by the fraction of n-hexane with 85.96% of inhibition percentage. The ethanol extract, n-hexane, and ethyl acetate fractions in Syzygium samarangense leaves did not have laxative and anorexic effect. It also could not decrease fat deposition in liver organ and abdominal fat tissue.