Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment

被引：21

作者：

Fossey, John S. ^{[1
]}

Anslyn, Eric V. ^{[2
]}

Brittain, William D. G. ^{[1
]}

Bull, Steven D. ^{[3
]}

Chapin, Brette M. ^{[1
,2
]}

Le Duff, Cecile S. ^{[1
]}

James, Tony D. ^{[3
]}

Lees, Glenn ^{[1
]}

Lim, Stephanie ^{[2
]}

Lloyd, Jennifer A. C. ^{[1
]}

Manville, Charles V. ^{[1
]}

Payne, Daniel T. ^{[1
]}

Roper, Kimberley A. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

[3] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

JOURNAL OF CHEMICAL EDUCATION | 2017年 / 94卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

Second-Year Undergraduate; Organic Chemistry; Analytical Chemistry; Laboratory Instruction; Hands-On Learning/Manipulatives; Computer-Based Learning; Stereochemistry; Chirality/Optical Activity; Enantiomers; NMR Spectroscopy; CHIRAL DERIVATIZATION PROTOCOLS; BORONIC ACIDS; PURITY; ENANTIOPURITY; CHEMISTRY; ALCOHOLS; H-1-NMR; ASSAY;

D O I：

10.1021/acs.jchemed.6b00355

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by H-1 NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance-for supporting the experiment.

引用

页码：79 / 84

页数：6

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