Interpreting the Epstein-Barr Virus (EBV) Epigenome Using High-Throughput Data

被引：45

作者：

Arvey, Aaron ^{[1
,2
]}

Lo Tempera, Ita ^{[3
,4
]}

Lieberman, Paul M. ^{[5
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

[3] Temple Univ, Sch Med, Fels Canc Inst, Philadelphia, PA USA

[4] Temple Univ, Sch Med, Dept Microbiol, Philadelphia, PA USA

[5] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

VIRUSES-BASEL | 2013年 / 5卷 / 04期

关键词：

Epstein-Barr virus; gammaherpesvirus; chromatin; histone modification; CTCF; OriP; CELL-CYCLE; DNA-REPLICATION; CHROMATIN; GENOME; ORGANIZATION; EXPRESSION; EFFICIENT; ALIGNMENT; PLASMID; BINDING;

D O I：

10.3390/v5041042

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Epstein-Barr virus (EBV) double-stranded DNA genome is subject to extensive epigenetic regulation. Large consortiums and individual labs have generated a vast number of genome-wide data sets on human lymphoblastoid and other cell lines latently infected with EBV. Analysis of these data sets reveals important new information on the properties of the host and viral chromosome structure organization and epigenetic modifications. We discuss the mapping of these data sets and the subsequent insights into the chromatin structure and transcription factor binding patterns on latent EBV genomes. Colocalization of multiple histone modifications and transcription factors at regulatory loci are considered in the context of the biology and regulation of EBV.

引用

页码：1042 / 1054

页数：13

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