Texture analysis of T1-w and T2-w MR images allows a quantitative evaluation of radiation-induced changes of internal obturator muscles after radiotherapy for prostate cancer

被引:13
作者
Scalco, Elisa [1 ]
Rancati, Tiziana [2 ]
Pirovano, Ileana [1 ]
Mastropietro, Alfonso [1 ]
Palorini, Federica [2 ]
Cicchetti, Alessandro [2 ]
Messina, Antonella [3 ]
Avuzzi, Barbara [4 ]
Valdagni, Riccardo [2 ,4 ,5 ]
Rizzo, Giovanna [1 ]
机构
[1] CNR, Inst Mol Bioimaging & Physiol, Segrate, Italy
[2] Fdn IRCCS Ist Nazl Tumori, Prostate Canc Program, Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Radiol, Milan, Italy
[4] Fdn IRCCS Ist Nazl Tumori, Radiat Oncol 1, Milan, Italy
[5] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy
关键词
dose-response curves; external beam radiotherapy; internal obturator muscles; multiparametric MRI; texture analysis; DOSE-SURFACE MAPS; URINARY-INCONTINENCE; FEATURES; VOLUME; HETEROGENEITY; HEAD; THERAPY; IMPACT;
D O I
10.1002/mp.12798
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PurposeTo investigate the potential of texture analysis applied on T2-w and postcontrast T1-w images acquired before radiotherapy for prostate cancer (PCa) and 12months after its completion in quantitatively characterizing local radiation effect on the muscular component of internal obturators, as organs potentially involved in urinary toxicity. MethodsT2-w and postcontrast T1-w MR images were acquired at 1.5T before treatment (MRI1) and at 12months of follow-up (MRI2) in 13 patients treated with radiotherapy for PCa. Right and left internal obturator muscle contours were manually delineated upon MRI1 and then automatically propagated on MRI2 by an elastic registration method. Planning CT images were coregistered to both MRIs and dose maps were deformed accordingly. A high-dose region receiving >55Gy and a low-dose region receiving <55Gy were identified in each muscle volume. Eighteen textural features were extracted from each region of interest and differences between MRI1 and MRI2 were evaluated. ResultsA signal increase was highlighted in both T2-w and T1-w images in the portion of the obturators near the prostate, i.e., in the region receiving medium-high doses. A change in the spatial organization was identified, as an increase in homogeneity and a decrease in contrast and complexity, compatible with an inflammatory status. In particular, the region receiving medium-high doses presented more significant or, at least, stronger differences. ConclusionsTexture analysis applied on T1-w and T2-w MR images has demonstrated its ability in quantitative evaluating radiation-induced changes in obturator muscles after PCa radiotherapy.
引用
收藏
页码:1518 / 1528
页数:11
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