The effect of ionic strength on the mechanical, structural and transport properties of peptide hydrogels

被引：46

作者：

Feng, Yue ^{[1
]}

Taraban, Marc ^{[2
]}

Yu, Y. Bruce ^{[1
,2
]}

机构：

[1] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[2] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

来源：

SOFT MATTER | 2012年 / 8卷 / 46期

关键词：

CONTROLLED-RELEASE; OLIGOPEPTIDE; DIFFUSION; ELASTICITY; SCAFFOLDS; PROTEINS; GELATION; MODULUS; MODEL;

D O I：

10.1039/c2sm26572a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

It is found that the elastic modulus of a peptide hydrogel increases linearly with the logarithm of its ionic strength. This result indicates that the elastic modulus of this class of hydrogels can be tuned by the ionic strength in a highly predictable manner. Small-angle X-ray scattering studies reveal that higher ionic strength leads to thinner but more rigid peptide fibers that are packed more densely. The self-diffusion coefficient of small molecules inside the hydrogel decreases linearly with its ionic strength, but this decrease is mainly a salt effect rather than diffusion barriers imposed by the hydrogel matrix.

引用

页码：11723 / 11731

页数：9

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