Three-dimensional quantitative phase imaging of blood coagulation structures by optical projection tomography in flow cytometry using digital holographic microscopy

被引：16

作者：

Funamizu, Hideki ^{[1
]}

Aizu, Yoshihisa ^{[1
]}

机构：

[1] Muroran Inst Technol, Div Prod Syst Engn, Muroran, Hokkaido, Japan

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2019年 / 24卷 / 03期

关键词：

digital holographic microscopy; red blood cell; blood coagulation; optical projection tomography; quantitative phase imaging; flow cytometry; CELLS; IDENTIFICATION; CLOT;

D O I：

10.1117/1.JBO.24.3.031012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood coagulation is an important role in the hemostasis process. In the observation using microscopies, an aggregation structure of red blood cells indicates the degree of blood coagulation. Recently, it has been proposed that digital holographic microscopy (DHM) is a powerful tool for biomedical cell imaging on the basis of quantitative phase information. DHM has the advantage in that the real-time and three-dimensional (3-D) quantitative phase imaging can be realized in the wide field of view, which means that the 3-D morphological parameters of biological cells without a staining process are obtained in real time. We report the complete 3-D quantitative phase imaging of blood coagulation structures by optical projection tomography in a flow cytometry using DHM. (C) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：6

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