Potential Role of Circulating Tumor Cell Detection and Monitoring in Breast Cancer: A Review of Current Evidence

被引：32
作者：
Banys-Paluchowski, Malgorzata [1 ]
Krawczyk, Natalia [2 ]
Fehm, Tanja [2 ]
机构：
[1] Marien Hosp, Dept Gynecol & Obstet, Hamburg, Germany
[2] Univ Duesseldorf, Dept Obstet & Gynecol, Dusseldorf, Germany
来源：
FRONTIERS IN ONCOLOGY | 2016年 / 6卷
关键词：
breast cancer; disseminated tumor cell; circulating tumor cell; prognosis; biomarkers; DIFFERENT PROGNOSTIC VALUE; BONE-MARROW; PERIPHERAL-BLOOD; POOLED ANALYSIS; HER2; STATUS; NEOADJUVANT CHEMOTHERAPY; PREDICTIVE-VALUE; LIQUID BIOPSY; STAGE-I; RT-PCR;
D O I：
10.3389/fonc.2016.00255
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The phenomenon of hematogenous tumor cell dissemination in patients with solid tumors has been extensively explored over the last decades. Breast cancer research investigated at first disseminated tumor cells in the bone marrow; however, the focus soon moved to circulating tumor cells (CTCs) in the peripheral blood as blood is easily accessible without an invasive procedure. The prognostic significance of CTC presence has been shown in large studies both in adjuvant and metastatic setting and commercially available detection assays have been evaluated for monitoring in clinical trials. Beyond detection and enumeration of CTCs, the characterization of single tumor cells may enhance our knowledge on disease progression and thus optimize treatment choices.
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页数：9
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