The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

被引：50

作者：

Akesson, Anna ^{[1
]}

Cardenas, Marite ^{[1
]}

Elia, Giuliano ^{[2
]}

Monopoli, Marco P. ^{[2
,3
]}

Dawson, Kenneth A. ^{[2
,3
]}

机构：

[1] Univ Copenhagen, Inst Chem & Nanosci Ctr, DK-2100 Copenhagen, Denmark

[2] Natl Univ Ireland Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland

[3] Natl Univ Ireland Univ Coll Dublin, Ctr BioNano Interact, Sch Chem & Chem Biol, Dublin 4, Ireland

来源：

RSC ADVANCES | 2012年 / 2卷 / 30期

关键词：

HUMAN SERUM-ALBUMIN; POLY(AMIDOAMINE) DENDRIMERS; NANOPARTICLE SIZE; DOXORUBICIN; INTERFACE; COMPLEXES; POLYMERS; RELEASE; SYSTEMS;

D O I：

10.1039/c2ra21866f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

引用

页码：11245 / 11248

页数：4

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