Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging

被引:383
作者
He, Weiwei [1 ,2 ]
Zhou, Yu-Ting [1 ,5 ]
Warner, Wayne G. [1 ]
Hu, Xiaona [3 ]
Wu, Xiaochun [3 ]
Zheng, Zhi [2 ]
Boudreau, Mary D. [4 ]
Yin, Jun-Jie [1 ]
机构
[1] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA
[2] Xuchang Univ, Inst Surface Micro & Nano Mat, Key Lab Micronano Mat Energy Storage & Convers He, Xuchang 461000, Henan, Peoples R China
[3] Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China
[4] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA
[5] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA
关键词
Au nanoparticles; Hydroxyl radicals; Oxygen; ROS; Nanosafety; ESR; GOLD NANOPARTICLES; DEPENDENT GENERATION; FREE-RADICALS; SIZE; OXIDASE; CYTOTOXICITY; BIOLOGY; CELLS; ION;
D O I
10.1016/j.biomaterials.2012.10.010
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Gold nanoparticles have received a great deal of interest due to their unique optical and catalytic properties and biomedical applications. Developing applications as well as assessing associated risks requires an understanding of the interactions between Au nanoparticles (NPs) and biologically active substances. In this paper, electron spin resonance spectroscopy (ESR) was used to investigate the catalytic activity of Au NPs in biologically relevant reactions. We report here that Au NPs can catalyze the rapid decomposition of hydrogen peroxide. Decomposition of hydrogen peroxide is accompanied by the formation of hydroxyl radicals at lower pH and oxygen at higher pH. In addition, we found that, mimicking SOD, Au NPs efficiently catalyze the decomposition of superoxide. These results demonstrate that Au NPs can act as SOD and catalase mimetics. Since reactive oxygen species are biologically relevant products being continuously generated in cells, these results obtained under conditions resembling different biological microenvironments may provide insights for evaluating risks associated with Au NPs. Published by Elsevier Ltd.
引用
收藏
页码:765 / 773
页数:9
相关论文
共 44 条
[1]   Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles [J].
Asati, Atul ;
Santra, Santimukul ;
Kaittanis, Charalambos ;
Nath, Sudip ;
Perez, J. Manuel .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (13) :2308-2312
[2]   Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity [J].
Boisselier, Elodie ;
Astruc, Didier .
CHEMICAL SOCIETY REVIEWS, 2009, 38 (06) :1759-1782
[3]   Gold nanocages: Engineering their structure for biomedical applications [J].
Chen, JY ;
Wiley, B ;
Li, ZY ;
Campbell, D ;
Saeki, F ;
Cang, H ;
Au, L ;
Lee, J ;
Li, XD ;
Xia, YN .
ADVANCED MATERIALS, 2005, 17 (18) :2255-2261
[4]   Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity [J].
Chen, Zhongwen ;
Yin, Jun-Jie ;
Zhou, Yu-Ting ;
Zhang, Yu ;
Song, Lina ;
Song, Mengjie ;
Hu, Sunling ;
Gu, Ning .
ACS NANO, 2012, 6 (05) :4001-4012
[5]   Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells [J].
Chithrani, BD ;
Ghazani, AA ;
Chan, WCW .
NANO LETTERS, 2006, 6 (04) :662-668
[6]   Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity [J].
Connor, EE ;
Mwamuka, J ;
Gole, A ;
Murphy, CJ ;
Wyatt, MD .
SMALL, 2005, 1 (03) :325-327
[7]   Nanostructured FeS as a Mimic Peroxidase for Biocatalysis and Biosensing [J].
Dai, Zhihui ;
Liu, Shaohua ;
Bao, Jianchun ;
Jui, Huangxian .
CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (17) :4321-4326
[8]   Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].
Daniel, MC ;
Astruc, D .
CHEMICAL REVIEWS, 2004, 104 (01) :293-346
[9]   Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods [J].
Durr, Nicholas J. ;
Larson, Timothy ;
Smith, Danielle K. ;
Korgel, Brian A. ;
Sokolov, Konstantin ;
Ben-Yakar, Adela .
NANO LETTERS, 2007, 7 (04) :941-945
[10]   Intrinsic peroxidase-like activity of ferromagnetic nanoparticles [J].
Gao, Lizeng ;
Zhuang, Jie ;
Nie, Leng ;
Zhang, Jinbin ;
Zhang, Yu ;
Gu, Ning ;
Wang, Taihong ;
Feng, Jing ;
Yang, Dongling ;
Perrett, Sarah ;
Yan, Xiyun .
NATURE NANOTECHNOLOGY, 2007, 2 (09) :577-583