Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis

被引：28
作者：
Azari, MF
Galle, A
Lopes, EC
Kurek, J
Cheema, SS
机构：
[1] Monash Univ, Dept Anat & Cell Biol, Clayton, Vic 3800, Australia
[2] AMRAD Corp Ltd, Richmond, Vic 3121, Australia
来源：
BRAIN RESEARCH | 2001年 / 922卷 / 01期
关键词：
leukemia inhibitory factor; SOD1 G93A transgenic mice; spinal motoneuron; neuroprotective;
D O I：
10.1016/S0006-8993(01)03156-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Leukemia inhibitory factor (LIF) is a survival factor for motoneurons. In this study we investigated whether intense systemic LIF therapy prevents the loss of lumbar motoneurons in the transgenic SOD1 G93A mouse model of familial amyotrophic lateral sclerosis. Treatment involved daily 25 mug/kg intraperitoneal injection for a period of 6 weeks starting at 70 days of age. Using the unbiased optical dissector technique, significant rescue of motoneurons in the LIF-treated group (3809 +/- 455) was found compared to the vehicle group (1085 +/- 140). (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：144 / 147
页数：4
相关论文
共 24 条
[1]   LEUKEMIA INHIBITORY FACTOR RESCUES MOTONEURONS FROM AXOTOMY-INDUCED CELL-DEATH [J].
CHEEMA, SS ;
RICHARDS, LJ ;
MURPHY, M ;
BARTLETT, PF .
NEUROREPORT, 1994, 5 (08) :989-992
[2]   RETROGRADE AXONAL-TRANSPORT OF LIF IS INCREASED BY PERIPHERAL-NERVE INJURY - CORRELATION WITH INCREASED LIF EXPRESSION IN DISTAL NERVE [J].
CURTIS, R ;
SCHERER, SS ;
SOMOGYI, R ;
ADRYAN, KM ;
IP, NY ;
ZHU, Y ;
LINDSAY, RM ;
DISTEFANO, PS .
NEURON, 1994, 12 (01) :191-204
[3]  
DAVIS I, 2000, P AUST SOC CLIN EXP, V7, P74
[4]   Transgenic animal models of familial amyotrophic lateral sclerosis [J].
Gurney, ME .
JOURNAL OF NEUROLOGY, 1997, 244 (Suppl 2) :S15-S20
[5]   MEMBERS OF SEVERAL GENE FAMILIES INFLUENCE SURVIVAL OF RAT MOTONEURONS IN-VITRO AND IN-VIVO [J].
HUGHES, RA ;
SENDTNER, M ;
THOENEN, H .
JOURNAL OF NEUROSCIENCE RESEARCH, 1993, 36 (06) :663-671
[6]   NEUROPROTECTIVE EFFECT OF CHOLINERGIC DIFFERENTIATION FACTOR LEUKEMIA INHIBITORY FACTOR ON WOBBLER MURINE MOTOR-NEURON DISEASE [J].
IKEDA, K ;
IWASAKI, Y ;
TAGAYA, N ;
SHIOJIMA, T ;
KINOSHITA, M .
MUSCLE & NERVE, 1995, 18 (11) :1344-1347
[7]   HISTOMETRIC EFFECTS OF CILIARY NEUROTROPHIC FACTOR IN WOBBLER MOUSE MOTOR-NEURON DISEASE [J].
IKEDA, K ;
WONG, V ;
HOLMLUND, TH ;
GREENE, T ;
CEDARBAUM, JM ;
LINDSAY, RM ;
MITSUMOTO, H .
ANNALS OF NEUROLOGY, 1995, 37 (01) :47-54
[8]   EFFECTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR ON MOTOR DYSFUNCTION IN WOBBLER MOUSE MOTOR-NEURON DISEASE [J].
IKEDA, K ;
KLINKOSZ, B ;
GREENE, T ;
CEDARBAUM, JM ;
WONG, V ;
LINDSAY, RM ;
MITSUMOTO, H .
ANNALS OF NEUROLOGY, 1995, 37 (04) :505-511
[9]  
Kasarskis EJ, 1999, NEUROLOGY, V52, P1427
[10]   ESSENTIAL FUNCTION OF LIF RECEPTOR IN MOTOR-NEURONS [J].
LI, M ;
SENDTNER, M ;
SMITH, A .
NATURE, 1995, 378 (6558) :724-727
123