Biodegradable nanoparticles for gene therapy technology

被引：44

作者：

Hosseinkhani, Hossein ^{[1
,2
,3
]}

He, Wen-Jie ^{[1
]}

Chiang, Chiao-Hsi ^{[2
]}

Hong, Po-Da ^{[1
,4
]}

Yu, Dah-Shyong ^{[3
,5
]}

Domb, Abraham J. ^{[6
,7
]}

Ou, Keng-Liang ^{[8
,9
,10
]}

机构：

[1] Natl Taiwan Univ Sci & Technol Taiwan Tech, Grad Inst Biomed Engn, Taipei 10607, Taiwan

[2] Natl Def Med Ctr, Sch Pharm, Taipei 11490, Taiwan

[3] Natl Def Med Ctr, Nanomed Res Ctr, Taipei 114, Taiwan

[4] Natl Taiwan Univ Sci & Technol Taiwan Tech, Dept Mat Sci & Engn, Taipei 10607, Taiwan

[5] Triserv Gen Hosp, Div Urol, Taipei, Taiwan

[6] Hebrew Univ Jerusalem, Inst Drug Res, Sch Pharm, Fac Med,Ctr Nanosci & Nanotechnol, IL-91120 Jerusalem, Israel

[7] Hebrew Univ Jerusalem, Alex Grass Ctr Drug Design & Synth, IL-91120 Jerusalem, Israel

[8] Taipei Med Univ, Coll Oral Med, Res Ctr Biomed Devices & Prototyping Prod, Taipei, Taiwan

[9] Taipei Med Univ, Coll Oral Med, Grad Inst Biomed Mat & Engn, Res Ctr Biomed Implants & Microsurg Devices, Taipei, Taiwan

[10] Taipei Med Univ, Shuang Ho Hosp, Dept Dent, Taipei 110, Taiwan

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2013年 / 15卷 / 07期

关键词：

Gene therapy; Viral vectors; Non-viral vectors; DNA; Gene expression; SEE VOL. 232; MESENCHYMAL STEM-CELLS; ECTOPIC BONE-FORMATION; REPEATED RGD SEQUENCES; IN-VITRO TRANSFECTION; PLASMID DNA; PEPTIDE-AMPHIPHILE; OSTEOGENIC DIFFERENTIATION; DEXTRAN-SPERMINE; CATIONIZED GELATIN;

D O I：

10.1007/s11051-013-1794-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid propagations in materials technology together with biology have initiated great hopes in the possibility of treating many diseases by gene therapy technology. Viral and non-viral gene carriers are currently applied for gene delivery. Non-viral technology is safe and effective for the delivery of genetic materials to cells and tissues. Non-viral systems are based on plasmid expression containing a gene encoding a therapeutic protein and synthetic biodegradable nanoparticles as a safe carrier of gene. Biodegradable nanoparticles have shown great interest in drug and gene delivery systems as they are easy to be synthesized and have no side effect in cells and tissues. This review provides a critical view of applications of biodegradable nanoparticles on gene therapy technology to enhance the localization of in vitro and in vivo and improve the function of administered genes.

引用

页数：15

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