XANTHONE DERIVATIVES FROM THE FERMENTATION PRODUCTS OF AN ENDOPHYTIC FUNGUS OF PHOMOPSIS AMYGDALI

被引：5

作者：

Hu, Qiufen ^{[1
,2
]}

Niu, Deyun ^{[1
,2
]}

Yang, Shuai ^{[3
]}

Cao, Hongyun ^{[3
]}

Meng, Chunyang ^{[1
,2
]}

Yang, Haiyin ^{[1
,2
]}

Gao, Xuemei ^{[1
,2
]}

Du, Gang ^{[1
,2
]}

机构：

[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Chem Ethn Med Resources, Kunming 650031, Peoples R China

[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China

[3] Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China

来源：

HETEROCYCLES | 2013年 / 87卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Fermenation Product of a Phomopsis Fungus; Xanthone; Cytotoxicity; Structure Elucidation; BIOLOGICAL-ACTIVITY; METABOLITES;

D O I：

10.3987/COM-13-12798

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new xanthones, 1,5-dihydroxy-3-(2-oxopropyl)-6-methoxy-carbonylxanthone (1) and 1-hydroxy-3-(2-oxopropyl)-8-methoxycarbonylxanthone (2), together with four known xanthones (3-6) were isolated from the fermentation products of a Phomopsis fungus. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed high cytotoxicity against A549 and PC3 cell with IC50 values of 3.5 and 2.8 mu M. Compound 2 showed high cytotoxicity against PC3 cell with IC50 value of 2.4 mu M. The other compounds also showed moderate cytotoxicity for some tested cell lines with IC50 values between 5.2-8.6 mu M.

引用

页码：2103 / 2108

页数：6

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