Mesenchymal Transformation: The Rosetta Stone of Glioblastoma Pathogenesis and Therapy Resistance

被引：44

作者：

Azam, Zulfikar ^{[1
,2
]}

To, Shing-Shun Tony ^{[2
]}

Tannous, Bakhos A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Neurol Dept, Neurooncol Div, Expt Therapeut & Mol Imaging Unit, Boston, MA 02129 USA

[2] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong 999077, Peoples R China

来源：

ADVANCED SCIENCE | 2020年 / 7卷 / 22期

基金：

美国国家卫生研究院;

关键词：

clinical outcome; glioblastoma (GBM); mesenchymal transition; molecular subtypes; therapy responses; tumor microenvironment; GLIOMA STEM-CELLS; ADJUVANT TEMOZOLOMIDE; TARGETING ZEB1; TRANSITION; BRAIN; DIFFERENTIATION; MIGRATION; SUBTYPES; EXPRESSION; INVASION;

D O I：

10.1002/advs.202002015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms of cancers. The high level of inter- and intratumoral heterogeneity along with its biological location, the brain, are major barriers against effective treatment. Molecular and single cell analysis identifies different molecular subtypes with varying prognosis, while multiple subtypes can reside in the same tumor. Cellular plasticity among different subtypes in response to therapies or during recurrence adds another hurdle in the treatment of GBM. This phenotypic shift is induced and sustained by activation of several pathways within the tumor itself, or microenvironmental factors. In this review, the dynamic nature of cellular shifts in GBM and how the tumor (immune) microenvironment shapes this process leading to therapeutic resistance, while highlighting emerging tools and approaches to study this dynamic double-edged sword are discussed.

引用

页数：13

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