N-Heterocyclic Carbene-Palladium(II)-1-Methylimidazole Complex Catalyzed α-Arylation of Oxindoles with Aryl Chlorides and Aerobic Oxidation of the Products in a One-Pot Procedure

被引：63

作者：

Xiao, Zheng-Kang ^{[1
]}

Yin, Hui-Ying ^{[1
]}

Shao, Li-Xiong ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 06期

关键词：

CROSS-COUPLING REACTIONS; SYSTEMS;

D O I：

10.1021/ol400186b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

NHC-Pd(II)-Im complex 1 was found to be an effective catalyst for the alpha-arylation of unprotected oxindoles with aryl chlorides to give products 4 in 44-98% yields under a N-2 atmosphere. Furthermore, if the reactions were first performed under conditions identical to those for the alpha-arylation reaction for 12 hand then exposed to air for another 3 h, 3-aryl-3-hydroxy-2-oxindoles 5 can be obtained in 49-84% yields In a one-pot procedure.

引用

页码：1254 / 1257

页数：4

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