Leucine-Rich Repeat Kinase 2 for Beginners: Six Key Questions

被引：32

作者：

Kett, Lauren R. ^{[1
,2
]}

Dauer, William T. ^{[1
,3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Neurol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Grad Program, Dept Neurosci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2012年 / 2卷 / 03期

关键词：

AUTOSOMAL-DOMINANT PARKINSONISM; DISEASE-ASSOCIATED MUTATIONS; COMMON LRRK2 MUTATION; LEUCINE-RICH-REPEAT-KINASE-2; LRRK2; DOPAMINERGIC-NEURONS; 14-3-3; BINDING; GTP-BINDING; RISK-FACTOR; ROC DOMAIN; PHOSPHORYLATION;

D O I：

10.1101/cshperspect.a009407

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.

引用

页数：10

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