How to RESPOND to Modern Challenges for People Living with HIV: A Profile for a New Cohort Consortium

被引：27

作者：

Neesgaard, Bastian ^{[1
]}

Mocroft, Amanda ^{[2
]}

Greenberg, Lauren ^{[2
]}

Larsen, Jakob Friis ^{[1
]}

Wandeler, Gilles ^{[3
]}

Zangerle, Robert ^{[4
]}

Gunthard, Huldrych ^{[5
,6
]}

Smith, Colette ^{[7
]}

De Wit, Stephane ^{[8
]}

Mussini, Cristina ^{[9
]}

Castagna, Antonella ^{[10
]}

Monforte, Antonella D'Arminio ^{[11
]}

Vehreschild, Joerg Janne ^{[12
]}

Wasmuth, Jan-Christian ^{[13
,14
]}

Pradier, Christian ^{[15
,16
]}

Chkhartishvili, Nikoloz ^{[17
]}

Wit, Ferdinand W. N. M. ^{[18
]}

Law, Matthew ^{[19
]}

Sonnerborg, Anders ^{[20
]}

Bruguera, Andreau ^{[21
]}

Stephan, Christoph ^{[22
]}

Vannappagari, Vani ^{[23
]}

Haubrich, Richard ^{[24
]}

Kirk, Ole ^{[1
]}

Podlekareva, Daria ^{[1
]}

Kowalska, Justyna ^{[25
]}

Raben, Dorthe ^{[1
]}

Rockstroh, Juergen ^{[13
,14
]}

Peters, Lars ^{[1
]}

Parades, Roger ^{[26
]}

Grabmeier-Pfistershammer, Katharina ^{[27
]}

Scherrer, Alexandra ^{[5
,6
]}

Johnson, Margaret ^{[7
]}

Necsoi, Coca ^{[8
]}

Borghi, Vanni ^{[9
]}

Muccini, Camilla ^{[10
]}

Tserstvadze, Tengiz ^{[17
]}

Petoumenos, Kathy ^{[19
]}

Volny-Anne, Alain ^{[28
]}

Lundgren, Jens ^{[1
]}

Ryom, Lene ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Infect Dis, CHIP, Rigshospitalet, Copenhagen, Denmark

[2] UCL, Inst Global Hlth, Ctr Clin Res Epidemiol Modelling & Evaluat CREME, London, England

[3] Univ Bern, Bern Univ Hosp, Dept Infect Dis, Bern, Switzerland

[4] Med Univ Innsbruck, Austrian HIV Cohort Study AHIVCOS, Innsbruch, Austria

[5] Univ Hosp Zurich, Div Infect Dis, Zurich, Switzerland

[6] Univ Hosp Zurich, Hosp Epidemiol, Zurich, Switzerland

[7] Royal Free HIV Cohort, London, England

[8] St Pierre Univ Hosp Bruxelles, Dept Infect Dis, Brussels, Belgium

[9] Univ Modena, Modena HIV Cohort, Modena, Italy

[10] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Milan, Italy

[11] ASST Santi Paolo & Carlo, Italian Cohort Naive Antiretrovirals ICONA, Milan, Italy

[12] Univ Hosp Cologne, Cologne, Germany

[13] Univ Klinikum Bonn, Bonn, Germany

[14] Med Fak, Bonn, Germany

[15] Univ Cote dAzur, Nice HIV Cohort, Nice, France

[16] CHU Nice, Nice, France

[17] Infect Dis AIDS & Clin Immunol Res Ctr, Georgian Natl AIDS Hlth Informat Syst AIDS HIS, Tbilisi, Georgia

[18] Stichting HIV Monitoring, AIDS Therapy Evaluat Netherlands ATHENA Cohort, Amsterdam, Netherlands

[19] UNSW Sidney, Australian HIV Observat Database AHOD, Sydney, NSW, Australia

[20] Karolinska Univ Hosp, Swedish InfCare HIV Cohort, Stockholm, Sweden

[21] Ctr Estudis Epidemiol ITS & VIH Catalunya CEEISCA, PISCIS Cohort Study, Badalona, Spain

[22] Johann Wolfgang Goethe Univ Hosp, Frankfurt HIV Cohort Study, Frankfurt, Germany

[23] ViiV Healthcare, Res Triangle Pk, NC USA

[24] Gilead Sci, Foster City, CA USA

[25] Med Univ Warsaw, Warsaw, Poland

[26] Hosp Badalona Germans Trias & Pujol, Badalona, Spain

[27] Med Univ Wien, Austrian HIV Cohort Study AHIVCOS, Vienna, Austria

[28] European AIDS Treatment Grp EATG, Brussels, Belgium

来源：

MICROORGANISMS | 2020年 / 8卷 / 08期

关键词：

HIV; cohort; observational study; hepatitis; public health; tuberculosis; pharmacovigilance; ANTIRETROVIRAL THERAPY; RISK;

D O I：

10.3390/microorganisms8081164

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases. Methods: RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12. Results: Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naive, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/mu L (438-830). Malignancies (n= 361) and cardiovascular disease (n= 168) were the predominant reported clinical events. Conclusion: RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.

引用

页码：1 / 17

页数：16

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