Spectroscopic thermoacoustic imaging of water and fat composition

被引：61

作者：

Bauer, Daniel R. ^{[1
,2
,3
]}

Wang, Xiong ^{[4
]}

Vollin, Jeff ^{[3
]}

Xin, Hao ^{[4
]}

Witte, Russell S. ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Med Imaging, Tucson, AZ 85724 USA

[2] Univ Arizona, Coll Opt Sci, Tucson, AZ 85724 USA

[3] Raytheon Corp, Raytheon Missile Syst, Tucsonm, AZ 85736 USA

[4] Univ Arizona, Dept Elect & Comp Engn, Tucson, AZ 85724 USA

来源：

APPLIED PHYSICS LETTERS | 2012年 / 101卷 / 03期

关键词：

MICROWAVE DIELECTRIC-PROPERTIES; BIOLOGICAL TISSUES; PHOTOACOUSTIC-SPECTROSCOPY; BREAST TISSUES; TUMOR-TISSUES; TOMOGRAPHY;

D O I：

10.1063/1.4737414

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

During clinical studies, thermoacoustic imaging (TAI) failed to reliably identify malignant breast tissue. To increase detection capability, we propose spectroscopic TAI to differentiate samples based on the slope of their dielectric absorption. Phantoms composed of different ratios of water and fat were imaged using excitation frequencies between 2.7 and 3.1 GHz. The frequency-dependent slope of the TA signal was highly correlated with that of its absorption coefficient (R-2 = 0.98 and p < 0.01), indicating spectroscopic TAI can distinguish materials based on their intrinsic dielectric properties. This approach potentially enhances cancer detection due to the increased water content of many tumors. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4737414]

引用

页数：4

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