Prospects in the Total Synthesis of Protein Therapeutics

被引：22
作者：
Chalker, Justin M. [1 ]
机构：
[1] Univ Tulsa, Dept Chem & Biochem, Tulsa, OK 74104 USA
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2013年 / 81卷 / 01期
关键词：
biologic; biopharmaceutical; native chemical ligation; peptide ligation; protein synthesis; protein therapeutic; NATIVE CHEMICAL LIGATION; SUGAR-ASSISTED LIGATION; CYSTEINE-FREE PEPTIDE; GLYCOPEPTIDE LIGATION; STAUDINGER LIGATION; INTERFERON-BETA; DESULFURIZATION; ERYTHROPOIETIN; OLIGOSACCHARIDES; GLYCOPROTEIN;
D O I：
10.1111/cbdd.12007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success and growing use of biologic-level pharmaceuticals is the development of methods for their precise synthesis. This review highlights the emerging techniques for the total synthesis of proteins, with a special focus on the possibility of accessing therapeutic targets through chemoselective peptide ligations.
引用
收藏
页码：122 / 135
页数：14
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