Molecular basis of chronic stress-induced hippocampal lateral asymmetry in rats and impact on learning and memory

被引:4
作者
Spasojevic, N. [1 ]
Jovanovic, P. [1 ]
Dronjak, S. [1 ]
机构
[1] Univ Belgrade, Inst Nucl Sci Vinca, Lab Mol Biol & Endocrinol, Belgrade, Serbia
关键词
asymmetry; hippocampus; noradrenaline; memory; rats; GENE-EXPRESSION; NOREPINEPHRINE; MODULATION; ENZYMES; BDNF;
D O I
10.1556/APhysiol.100.2013.4.3
中图分类号
学科分类号
摘要
Neurochemical lateralization has been demonstrated in the rat brain suggesting that such lateralization might contribute to behavior. Thus, the aim of the present study was to examine neurochemical asymmetry in the hippocampus, molecular basis of neurochemical lateralization and its impact on spatial learning and memory. Changes in noradrenaline content, tyrosine hydroxylase (TH) were studied in the right and left hippocampus of naive control and chronically isolated rats, by applying TaqMan RT-PCR and Western blot analysis. Hippocampal-based spatial learning and memory were evaluated using the Barnes maze. In control rats an asymmetrical right-left distribution of noradrenaline content and gene expression of catecholamine synthesizing enzyme was found. Chronic psychosocial stress further emphasized asymmetry. Isolation stress reduced noradrenaline content only in the right hippocampus. No changes were observed in gene expression and protein levels of TH in the right hippocampus, whereas expression of catecholamine synthesizing enzyme was elevated in the left hippocampus. Reduced noradrenaline content in the right hippocampus did not cause impairment in spatial learning and memory. Our findings suggest that chronic psychosocial stress reduces noradrenaline stores in the right hippocampus which may be caused by molecular asymmetry, but it does not affect spatial learning and memory.
引用
收藏
页码:388 / 394
页数:7
相关论文
共 23 条
[1]  
ABERCROMBIE ED, 1992, STRESS : NEUROENDOCRINE AND MOLECULAR APPROACHES, VOLS 1 AND 2, P29
[2]   An endogenous adrenoceptor ligand potentiates excitatory synaptic transmission in cultured hippocampal neurons [J].
Aubert, M ;
Guiramand, J ;
Croce, A ;
Roch, G ;
Szafarczyk, A ;
Vignes, M .
CEREBRAL CORTEX, 2001, 11 (09) :878-887
[3]   Hippocampal asymmetry in serotonergic modulation of learning and memory in rats [J].
Belcheva, I. ;
Tashev, R. ;
Belcheva, S. .
LATERALITY, 2007, 12 (06) :475-486
[4]   Recovery of Chronic Noise Exposure Induced Spatial Learning and Memory Deficits in Young Male Sprague-Dawley Rats [J].
Chen Chengzhi ;
Tang Yan ;
Jiang Xuejun ;
Li Xiang ;
Qi Youbin ;
Tu Baijie .
JOURNAL OF OCCUPATIONAL HEALTH, 2011, 53 (03) :157-163
[5]  
Chiu Kin, 2007, J Vis Exp, P269, DOI 10.3791/269
[6]  
Espina-Marchant P, 2006, BIOL RES, V39, P601, DOI 10.4067/S0716-97602006000500003
[7]  
Gavrilovic L, 2008, NEUROENDOCRINOL LETT, V29, P1015
[8]  
Gerendai Ida, 2004, Acta Physiologica Hungarica, V91, P1, DOI 10.1556/APhysiol.91.2004.1.1
[9]  
HECHT K, 1982, ACTA BIOL MED GER, V41, P641
[10]   Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: A magnetic resonance study [J].
Hui, Jiao-jie ;
Zhang, Zhi-jun ;
Liu, Shan-shan ;
Xi, Guang-jun ;
Zhang, Xiang-rong ;
Teng, Gao-Jun ;
Chan, Kevin C. ;
Wu, Ed X. ;
Nie, Bin-bin ;
Shan, Bao-ci ;
Li, Ling-jiang ;
Reynolds, Gavin P. .
BEHAVIOURAL BRAIN RESEARCH, 2011, 217 (01) :122-127