Laponite-based Nanomaterials for Biomedical Applications: A Review

被引:73
|
作者
Das, Sabya S. [1 ]
Neelam [2 ]
Hussain, Kashif [3 ]
Singh, Sima [4 ]
Hussain, Afzal [1 ]
Faruk, Abdul [5 ]
Tebyetekerwa, Mike [6 ]
机构
[1] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India
[2] NIMS Univ, Dept Pharmaceut Sci, Jaipur 303121, Rajasthan, India
[3] Gyani Inder Singh Inst Profess Studies, Dehra Dun 248003, Uttarakhand, India
[4] Univ KwaZulu Natal, Sch Hlth Sci, Coll Hlth Sci, ZA-4000 Durban, South Africa
[5] Hemwati Nandan Bahuguna Garhwal Univ, Dept Pharmaceut Sci, Srinagar, Uttarakhand, India
[6] Donghua Univ, Coll Mat Sci, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai, Peoples R China
关键词
Laponite (LAP); laponite-based nano-materials (LBNMs); applications; composition and characteristics; drug delivery and biosensor; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY-SYSTEMS; CROSS-LINKED PEO; NANOCOMPOSITE HYDROGELS; POLY(ETHYLENE GLYCOL); CONTROLLED-RELEASE; ANTITUMOR EFFICACY; POLYMERIC MICELLES; CARBON NANOTUBES; CANCER-THERAPY;
D O I
10.2174/1381612825666190402165845
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Laponite based nanomaterials (LBNMs) are highly diverse regarding their mechanical, chemical, and structural properties, coupled with shape, size, mass, biodegradability and biocompatibility. These ubiquitous properties of LBNMs make them appropriate materials for extensive applications. These have enormous potential for effective and targeted drug delivery comprised of numerous biodegradable materials which results in enhanced bioavailability. Moreover, the clay material has been explored in tissue engineering and bioimaging for the diagnosis and treatment of various diseases. The material has been profoundly explored for minimized toxicity of nanomedicines. The present review compiled relevant and informative data to focus on the interactions of laponite nanoparticles and application in drug delivery, tissue engineering, imaging, cell adhesion and proliferation, and in biosensors. Eventually, concise conclusions are drawn concerning biomedical applications and identification of new promising research directions.
引用
收藏
页码:424 / 443
页数:20
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