Stemformatics: Visualisation and sharing of stem cell gene expression

被引：51

作者：

Wells, Christine A. ^{[1
]}

Mosbergen, Rowland ^{[1
]}

Korn, Othmar ^{[2
]}

Choi, Jarny ^{[3
]}

Seidenman, Nick ^{[3
]}

Matigian, Nicholas A. ^{[4
]}

Vitale, Alejandra M. ^{[1
]}

Shepherd, Jill ^{[1
]}

机构：

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[2] Griffith Univ, Div Informat Serv, Nathan, Qld 4111, Australia

[3] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[4] Griffith Univ, Australian Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies, Nathan, Qld 4111, Australia

来源：

STEM CELL RESEARCH | 2013年 / 10卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

DATABASE; PLURIPOTENCY; COMMITMENT; STATES; KEGG;

D O I：

10.1016/j.scr.2012.12.003

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Genome-scale technologies are increasingly adopted by the stem cell research community, because of the potential to uncover the molecular events most informative about a stem cell state. These technologies also present enormous challenges around the sharing and visualisation of data derived from different laboratories or under different experimental conditions. Stemformatics is an easy to use, publicly accessible portal that hosts a large collection of exemplar stem cell data. It provides fast visualisation of gene expression across a range of mouse and human datasets, with transparent links back to the original studies. One difficulty in the analysis of stem cell signatures is the paucity of public pathways/gene lists relevant to stem cell or developmental biology. Stemformatics provides a simple mechanism to create, share and analyse gene sets, providing a repository of community-annotated stem cell gene lists that are informative about pathways, lineage commitment, and common technical artefacts. Stemformatics can be accessed at stemformatics.org. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

引用

页码：387 / 395

页数：9

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