Inflammation in uveal melanoma

被引：78
作者：
Bronkhorst, I. H. G. [1 ]
Jager, M. J. [1 ]
机构：
[1] LUMC, Dept Ophthalmol, NL-2300 Leiden, Netherlands
来源：
EYE | 2013年 / 27卷 / 02期
关键词：
uveal melanoma; tumour immunology; macrophages; lymphocytes; cytokines; hypoxia; TUMOR STROMA; IMMUNE CELLS; MONOSOMY; 3; CANCER; EXPRESSION; MACROPHAGES; PROGNOSIS; MUTATIONS; CYTOKINES; SURVIVAL;
D O I：
10.1038/eye.2012.253
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Leukocytic infiltration is a common feature of human cancers, including those that develop in immunoprivileged sites, such as the eye. The infiltration of myeloid and T cells into tumours is part of the host response against cancer. In uveal melanoma, high densities of immune cells seem to be involved in tumour progression, as they are associated with the loss of one chromosome 3. The nature of this tumour microenvironment might offer therapeutic opportunities. Eye (2013) 27, 217-223; doi:10.1038/eye.2012.253; published online 14 December 2012
引用
收藏
页码：217 / 223
页数：7
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