Inflammation in uveal melanoma

被引：78
作者：
Bronkhorst, I. H. G. [1 ]
Jager, M. J. [1 ]
机构：
[1] LUMC, Dept Ophthalmol, NL-2300 Leiden, Netherlands
来源：
EYE | 2013年 / 27卷 / 02期
关键词：
uveal melanoma; tumour immunology; macrophages; lymphocytes; cytokines; hypoxia; TUMOR STROMA; IMMUNE CELLS; MONOSOMY; 3; CANCER; EXPRESSION; MACROPHAGES; PROGNOSIS; MUTATIONS; CYTOKINES; SURVIVAL;
D O I：
10.1038/eye.2012.253
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Leukocytic infiltration is a common feature of human cancers, including those that develop in immunoprivileged sites, such as the eye. The infiltration of myeloid and T cells into tumours is part of the host response against cancer. In uveal melanoma, high densities of immune cells seem to be involved in tumour progression, as they are associated with the loss of one chromosome 3. The nature of this tumour microenvironment might offer therapeutic opportunities. Eye (2013) 27, 217-223; doi:10.1038/eye.2012.253; published online 14 December 2012
引用
收藏
页码：217 / 223
页数：7
相关论文
共 50 条
  • [31] Clinical Activity of Ipilimumab for Metastatic Uveal Melanoma
    Luke, Jason J.
    Callahan, Margaret K.
    Postow, Michael A.
    Romano, Emanuela
    Ramaiya, Nikhil
    Bluth, Mark
    Giobbie-Hurder, Anita
    Lawrence, Donald P.
    Ibrahim, Nageatte
    Ott, Patrick A.
    Flaherty, Keith T.
    Sullivan, Ryan J.
    Harding, James J.
    D'Angelo, Sandra
    Dickson, Mark
    Schwartz, Gary K.
    Chapman, Paul B.
    Wolchok, Jedd D.
    Hodi, F. Stephen
    Carvajal, Richard D.
    CANCER, 2013, 119 (20) : 3687 - 3695
  • [32] The use of pembrolizumab for the treatment of metastatic uveal melanoma
    Kottschade, Lisa A.
    McWilliams, Robert R.
    Markovic, Svetomir N.
    Block, Matthew S.
    Bisneto, Jose Villasboas
    Pham, Anthony Q.
    Esplin, Brandt L.
    Dronca, Roxana S.
    MELANOMA RESEARCH, 2016, 26 (03) : 300 - 303
  • [33] Expression and prognostic significance of iNOS in uveal melanoma
    Johansson, C. Christian
    Mougiakakos, Dimitrios
    Trocme, Eric
    All-Ericsson, Charlotta
    Economou, Mario A.
    Larsson, Olie
    Seregard, Stefan
    Kiessling, Rolf
    INTERNATIONAL JOURNAL OF CANCER, 2010, 126 (11) : 2682 - 2689
  • [34] Uveal melanoma-associated cancers revisited
    Alfaar, Ahmad Samir
    Saad, Anas
    Elzouki, Shiema
    Abdel-Rahman, Mohamed H.
    Strauss, Olaf
    Rehak, Matus
    ESMO OPEN, 2020, 5 (06)
  • [35] The Genetics of Uveal Melanoma: Overview and Clinical Relevance
    Riechardt, Aline Isabel
    Kilic, Emine
    Joussen, Antonia M.
    KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 2021, 238 (07) : 773 - 779
  • [36] Nuclear HER3 is associated with favorable overall survival in uveal melanoma
    Trocme, Eric
    Mougiakakos, Dimitrios
    Johansson, C. Christian
    All-Eriksson, Charlotta
    Economou, Mario A.
    Larsson, Olle
    Seregard, Stefan
    Kiessling, Rolf
    Lin, Yingbo
    INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (05) : 1120 - 1127
  • [37] Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease
    Achberger, Susan
    Aldrich, Wayne
    Tubbs, Raymond
    Crabb, John W.
    Singh, Arun D.
    Triozzi, Pierre L.
    MOLECULAR IMMUNOLOGY, 2014, 58 (02) : 182 - 186
  • [38] Genetic Features of Uveal Melanoma
    Sorrentino, Francesco Saverio
    Culiersi, Carola
    Florido, Antonio
    De Nadai, Katia
    Adamo, Ginevra Giovanna
    Nasini, Francesco
    Vivarelli, Chiara
    Mura, Marco
    Parmeggiani, Francesco
    GENES, 2024, 15 (11)
  • [39] Role of Epigenetics in Uveal Melanoma
    Li, Yongyun
    Jia, Renbing
    Ge, Shengfang
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017, 13 (04): : 426 - 433
  • [40] Genetic prognostication in uveal melanoma
    Dogrusoz, Mehmet
    Jager, Martine J.
    ACTA OPHTHALMOLOGICA, 2018, 96 (04) : 331 - 347
12345