Xanthone derivatives from Aspergillus sydowii, an endophytic fungus from the liverwort Scapania ciliata S. Lac and their immunosuppressive activities

被引：57

作者：

Song, Xian-Qin ^{[1
]}

Zhang, Xin ^{[1
]}

Han, Qiu-Ju ^{[2
]}

Li, Xiao-Bin ^{[1
]}

Li, Gang ^{[1
]}

Li, Rui-Juan ^{[1
]}

Jiao, Yang ^{[1
]}

Zhou, Jin-Chuan ^{[1
]}

Lou, Hong-Xiang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Nat Prod Chem,Key Lab Chem Biol, Jinan 250012, Peoples R China

[2] Shandong Univ, Sch Pharm, Inst Immunopharmacol & Immunotherapy, Jinan 250012, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2013年 / 6卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Endophytic fungus; Liverwort; Metabolites; Immunosuppressive activity; METABOLITES; DIVERSITY;

D O I：

10.1016/j.phytol.2013.03.012

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new xanthone derivatives, including two first reported containing sulfur as natural products: sydoxanthone A (1) and sydoxanthone B (2), and 13-O-acetylsydowinin B (3) were isolated from an endophytic fungus Aspergillus sydowii, occurring in the livewort Scapania ciliata S. Lac, together with seven known biosynthetically related compounds (4-10). Their structures were established primarily by NMR, UV and MS data. In vitro suppression test on the Con A- and LPS-induced proliferations of mouse splenic lymphocytes showed that compounds 7 and 8 displayed moderate immunosuppressive activities. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：318 / 321

页数：4

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