Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp ZJ-SY2

被引：47
作者：
Liu, Hongju [1 ,2 ]
Chen, Senhua [1 ]
Liu, Weiyang [2 ]
Liu, Yayue [1 ]
Huang, Xishan [1 ]
She, Zhigang [1 ,3 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China
[2] Guangdong Med Univ, Sch Pharm, Dongguan 523808, Peoples R China
[3] South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China
来源：
MARINE DRUGS | 2016年 / 14卷 / 12期
基金：
中国国家自然科学基金;
关键词：
polyketides; Penicillium sp; marine fungus; immunosuppressive activity; SESTERTERPENOIDS; METABOLITES; RITUXIMAB;
D O I：
10.3390/md14120217
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY2 isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 g/mL.
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