Hydrogen sulfide as a regulator of calcium channels

被引:63
作者
Munaron, Luca [1 ,2 ,3 ]
Avanzato, Daniele [1 ]
Moccia, Francesco [4 ]
Mancardi, Daniele [5 ]
机构
[1] Univ Turin, Dept Life Sci & Syst Biol, I-10124 Turin, Italy
[2] Univ Turin, Ctr Complex Syst Mol Biol & Med SysBioM, I-10124 Turin, Italy
[3] Univ Turin, Nanostruct Interfaces & Surfaces Ctr Excellence N, I-10124 Turin, Italy
[4] Univ Pavia, Dept Biol & Biotechnol Lazzaro Spallanzani, I-27100 Pavia, Italy
[5] Univ Turin, Dept Clin & Biol Sci, Orbassano, TO, Italy
关键词
H2S; Sulfhydration; Calcium channels; Regulation; Cell signaling; RECEPTOR POTENTIAL CHANNELS; SUBSTANCE-P RELEASE; TRPA1; ION-CHANNEL; T-TYPE; NITRIC-OXIDE; ENDOTHELIAL-CELLS; CA2+ ENTRY; NEUROGENIC INFLAMMATION; CARDIOVASCULAR-SYSTEM; SIGNALING MOLECULE;
D O I
10.1016/j.ceca.2012.07.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
An increasing body of evidence suggests the involvement of hydrogen sulfide (H2S) in different physiological and pathological processes. Similarly to the other gasotransmitters nitric oxide (NO) and carbon monoxide (CO), this bioactive compound is rapidly diffusible through the biological membranes and acts in a paracrine fashion. Despite the large amount of biological actions observed in vitro and in vivo upon stimulation with H2S donors, as well as by interfering with its synthesis, the molecular targets and mechanisms through which it exerts its intracellular effects are only partially known. A number of proteins are covalently modified by H2S through sulfhydration of specific cysteine residues. However, only in few cases their identity has been discovered and the functional role of this post-translational modification needs to be investigated in more detail. Great attention has been devoted to potassium channels, particularly K-ATP as they are considered key mediators of H2S-induced effects, and their sulfhydration has been clearly demonstrated. Recently, different authors reported the ability of H2S to interfere with calcium homeostasis in neurons, cardiomyocytes and endothelial cells. Since calcium signaling is involved in all cell processes, these observations attracted increasing attention from basic biology and medicine. Although some effects of H2S on calcium signals can be ascribed to K-ATP modulation, there is growing consensus about the existence of other targets for the gasotransmitter. Some of them are Ca2+-permeable channels. In this review we discuss the state of the art in this specific field, providing an updated report of H2S interaction with Ca2+ channels and its functional outcomes. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:77 / 84
页数:8
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