Antiretroviral Therapy Initiated During Acute HIV Infection Fails to Prevent Persistent T-Cell Activation

被引：45
|
作者：
Vinikoor, Michael J. [1 ]
Cope, Anna [1 ]
Gay, Cynthia L. [1 ]
Ferrari, Guido [2 ]
McGee, Kara S. [3 ]
Kuruc, Joann D. [1 ]
Lennox, Jeffrey L. [4 ]
Margolis, David M. [1 ]
Hicks, Charles B. [3 ]
Eron, Joseph J. [1 ]
机构：
[1] Univ N Carolina, Ctr Infect Dis, Dept Med, Chapel Hill, NC 27599 USA
[2] Duke Univ, Dept Surg, Durham, NC USA
[3] Duke Univ, Dept Med, Durham, NC USA
[4] Emory Univ, Dept Med, Atlanta, GA 30322 USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 62卷 / 05期
关键词：
acute HIV infection; antiretroviral therapy; immune activation; viral dynamics; NNRTIs; IMMUNE ACTIVATION; VIRAL LOAD; RECONSTITUTION; VIREMIA;
D O I：
10.1097/QAI.0b013e318285cd33
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Initiation of antiretroviral therapy during acute HIV-1 infection may prevent persistent immune activation. We analyzed longitudinal CD38+HLA-DR+ CD8+ T-cell percentages in 31 acutely infected individuals who started early (median 43 days since infection) and successful antiretroviral therapy, and maintained viral suppression through 96 weeks. Pretherapy a median of 72.6% CD8+ T cells were CD38+HLA-DR+, and although this decreased to 15.6% by 96 weeks, it remained substantially higher than seronegative controls (median 8.9%, P = 0.008). Shorter time to suppression predicted lower activation at 96 weeks. These results support the hypothesis that very early events in HIV-1 pathogenesis may result in prolonged immune dysfunction.
引用
收藏
页码：505 / 508
页数：4
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