Antiretroviral Therapy Initiated During Acute HIV Infection Fails to Prevent Persistent T-Cell Activation

被引：45

作者：

Vinikoor, Michael J. ^{[1
]}

Cope, Anna ^{[1
]}

Gay, Cynthia L. ^{[1
]}

Ferrari, Guido ^{[2
]}

McGee, Kara S. ^{[3
]}

Kuruc, Joann D. ^{[1
]}

Lennox, Jeffrey L. ^{[4
]}

Margolis, David M. ^{[1
]}

Hicks, Charles B. ^{[3
]}

Eron, Joseph J. ^{[1
]}

机构：

[1] Univ N Carolina, Ctr Infect Dis, Dept Med, Chapel Hill, NC 27599 USA

[2] Duke Univ, Dept Surg, Durham, NC USA

[3] Duke Univ, Dept Med, Durham, NC USA

[4] Emory Univ, Dept Med, Atlanta, GA 30322 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 62卷 / 05期

关键词：

acute HIV infection; antiretroviral therapy; immune activation; viral dynamics; NNRTIs; IMMUNE ACTIVATION; VIRAL LOAD; RECONSTITUTION; VIREMIA;

D O I：

10.1097/QAI.0b013e318285cd33

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Initiation of antiretroviral therapy during acute HIV-1 infection may prevent persistent immune activation. We analyzed longitudinal CD38+HLA-DR+ CD8+ T-cell percentages in 31 acutely infected individuals who started early (median 43 days since infection) and successful antiretroviral therapy, and maintained viral suppression through 96 weeks. Pretherapy a median of 72.6% CD8+ T cells were CD38+HLA-DR+, and although this decreased to 15.6% by 96 weeks, it remained substantially higher than seronegative controls (median 8.9%, P = 0.008). Shorter time to suppression predicted lower activation at 96 weeks. These results support the hypothesis that very early events in HIV-1 pathogenesis may result in prolonged immune dysfunction.

引用

页码：505 / 508

页数：4

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