Eukaryotic genomes are colonized by transposons whose uncontrolled activity causes genomic instability. The piRNA pathway silences transposons in animal gonads, yet how this is achieved molecularly remains controversial. Here, we show that the HMG protein Maelstrom is essential for Piwi-mediated silencing in Drosophila. Genome-wide assays revealed highly correlated changes in RNA polymerase II recruitment, nascent RNA output, and steady-state RNA levels of transposons upon loss of Piwi or Maelstrom. Our data demonstrate piRNA-mediated trans-silencing of hundreds of transposon copies at the transcriptional level. We show that Piwi is required to establish heterochromatic H3K9me3 marks on transposons and their genomic surroundings. In contrast, loss of Maelstrom affects transposon H3K9me3 patterns only mildly yet leads to increased heterochromatin spreading, suggesting that Maelstrom acts downstream of or in parallel to H3K9me3. Our work illustrates the widespread influence of transposons and the piRNA pathway on chromatin patterns and gene expression.
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
;
Sachidanandam, Ravi
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Sachidanandam, Ravi
;
Bourc'his, Deborah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM, U741, Inst Jacques Monod, F-75251 Paris 05, FranceCold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Bourc'his, Deborah
;
Schaefer, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM, U741, Inst Jacques Monod, F-75251 Paris 05, France
Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Schaefer, Christopher
;
Pezic, Dubravka
论文数: 0引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, AustriaCold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Pezic, Dubravka
;
Toth, Katalin Fejes
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Toth, Katalin Fejes
;
论文数: 引用数:
h-index:
机构:
Bestor, Timothy
;
Hannon, Gregory J.
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
;
van der Heijden, Godfried W.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
van der Heijden, Godfried W.
;
Castaneda, Julio
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Castaneda, Julio
;
Vagin, Vasily V.
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Vagin, Vasily V.
;
Hannon, Gregory J.
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Hannon, Gregory J.
;
Bortvin, Alex
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Ashe, Alyson
;
Sapetschnig, Alexandra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Sapetschnig, Alexandra
;
Weick, Eva-Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Weick, Eva-Maria
;
Mitchell, Jacinth
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27514 USA
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Mitchell, Jacinth
;
Bagijn, Marloes P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Bagijn, Marloes P.
;
Cording, Amy C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Cording, Amy C.
;
Doebley, Anna-Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Biol, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Doebley, Anna-Lisa
;
Goldstein, Leonard D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Goldstein, Leonard D.
;
Lehrbach, Nicolas J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Lehrbach, Nicolas J.
;
Le Pen, Jeremie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Le Pen, Jeremie
;
Pintacuda, Greta
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Scuola Normale Super Pisa, I-56126 Pisa, ItalyUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Pintacuda, Greta
;
Sakaguchi, Aisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Sakaguchi, Aisa
;
Sarkies, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Sarkies, Peter
;
Ahmed, Shawn
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27514 USA
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Ahmed, Shawn
;
Miska, Eric A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Buckley, Bethany A.
;
Burkhart, Kirk B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Burkhart, Kirk B.
;
Gu, Sam Guoping
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Dept Genet, Stanford, CA 94305 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Gu, Sam Guoping
;
Spracklin, George
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Spracklin, George
;
Kershner, Aaron
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USA
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Kershner, Aaron
;
Fritz, Heidi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USA
Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Fritz, Heidi
;
Kimble, Judith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USA
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Kimble, Judith
;
论文数: 引用数:
h-index:
机构:
Fire, Andrew
;
Kennedy, Scott
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
;
Sachidanandam, Ravi
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Sachidanandam, Ravi
;
Bourc'his, Deborah
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM, U741, Inst Jacques Monod, F-75251 Paris 05, FranceCold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Bourc'his, Deborah
;
Schaefer, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 07, INSERM, U741, Inst Jacques Monod, F-75251 Paris 05, France
Columbia Univ, Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Schaefer, Christopher
;
Pezic, Dubravka
论文数: 0引用数: 0
h-index: 0
机构:
Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, AustriaCold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Pezic, Dubravka
;
Toth, Katalin Fejes
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Toth, Katalin Fejes
;
论文数: 引用数:
h-index:
机构:
Bestor, Timothy
;
Hannon, Gregory J.
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
;
van der Heijden, Godfried W.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
van der Heijden, Godfried W.
;
Castaneda, Julio
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Castaneda, Julio
;
Vagin, Vasily V.
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Vagin, Vasily V.
;
Hannon, Gregory J.
论文数: 0引用数: 0
h-index: 0
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Hannon, Gregory J.
;
Bortvin, Alex
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Ashe, Alyson
;
Sapetschnig, Alexandra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Sapetschnig, Alexandra
;
Weick, Eva-Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Weick, Eva-Maria
;
Mitchell, Jacinth
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27514 USA
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Mitchell, Jacinth
;
Bagijn, Marloes P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Bagijn, Marloes P.
;
Cording, Amy C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Cording, Amy C.
;
Doebley, Anna-Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Biol, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Doebley, Anna-Lisa
;
Goldstein, Leonard D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Goldstein, Leonard D.
;
Lehrbach, Nicolas J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Lehrbach, Nicolas J.
;
Le Pen, Jeremie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Le Pen, Jeremie
;
Pintacuda, Greta
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Scuola Normale Super Pisa, I-56126 Pisa, ItalyUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Pintacuda, Greta
;
Sakaguchi, Aisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Sakaguchi, Aisa
;
Sarkies, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Sarkies, Peter
;
Ahmed, Shawn
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Univ N Carolina, Dept Biol, Chapel Hill, NC 27514 USA
Univ N Carolina, Curriculum Genet & Mol Biol, Chapel Hill, NC 27514 USAUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
Ahmed, Shawn
;
Miska, Eric A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, EnglandUniv N Carolina, Dept Genet, Chapel Hill, NC 27514 USA
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Buckley, Bethany A.
;
Burkhart, Kirk B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Burkhart, Kirk B.
;
Gu, Sam Guoping
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Pathol, Stanford, CA 94305 USA
Stanford Univ, Dept Genet, Stanford, CA 94305 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Gu, Sam Guoping
;
Spracklin, George
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Spracklin, George
;
Kershner, Aaron
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USA
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Kershner, Aaron
;
Fritz, Heidi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USA
Univ Wisconsin, Howard Hughes Med Inst, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Fritz, Heidi
;
Kimble, Judith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USA
Univ Wisconsin, Dept Biochem, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA
Kimble, Judith
;
论文数: 引用数:
h-index:
机构:
Fire, Andrew
;
Kennedy, Scott
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Lab Genet, Madison, WI 53706 USAUniv Wisconsin, Lab Genet, Madison, WI 53706 USA