Diclavatol and tetronic acids from Penicillium griseoroseum

被引：9

作者：

da Silva, Jose Vinicius ^{[1
]}

Fill, Taicia Pacheco ^{[1
]}

da Silva, Bianca Ferreira ^{[1
]}

Rodrigues-Fo, Edson ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

diclavatol; Penicillium griseoroseum; endophytic fungi; tetronic acids; DERIVATIVES; MECHANISM; CLAVATOL;

D O I：

10.1080/14786419.2011.647021

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In our continuous studies on the chemistry of the endophytic fungus Penicillium griseoroseum, an endophyte isolated from fruits of Coffea arabica, we isolated clavatol, a dimethylated tetraketide, and its dimer which appears to be a novel natural compound. The studies also resulted in the identification of two known tetronic acids, viridicatic acid and terrestric acid, found in ethyl acetate and n-butanol extracts. Spectroscopic studies using 1-D and 2-D NMR and MS/MS analysis were performed to determine the structures of these compounds, first reported by this Penicillium. Two other tetronic acids congeners were identified through HPLC/MS/MS studies, based on fragmentation pattern of ions produced from ionised tetronic acids, and UV light absorptions.

引用

页码：9 / 16

页数：8

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