Late-Stage Deoxyfluorination of Alcohols with PhenoFluor

被引：137

作者：

Sladojevich, Filippo ^{[1
]}

Arlow, Sophie I. ^{[1
]}

Tang, Pingping ^{[1
]}

Ritter, Tobias ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 07期

关键词：

MEDICINAL CHEMISTRY; NATURAL-PRODUCTS; FLUORINATION; TRIFLUOROMETHYLATION; HETEROCYCLES; VANCOMYCIN; FLUORIDES; CATALYSIS; REAGENT; AGENT;

D O I：

10.1021/ja3125405

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility. A series of simple guidelines for predicting the selectivity in substrates with multiple alcohols is given.

引用

页码：2470 / 2473

页数：4

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