Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy

被引：86
|
作者：
Mitamura, Y
Takeuchi, S
Matsuda, A
Tagawa, Y
Mizue, Y
Nishihira, J
机构：
[1] Toho Univ, Sakura Hosp, Dept Ophthalmol, Chiba 2858741, Japan
[2] Hokkaido Univ, Sch Med, Dept Ophthalmol, Sapporo, Hokkaido 060, Japan
[3] Hokkaido Univ, Sch Med, Cent Res Inst, Sapporo, Hokkaido 060, Japan
[4] Sapporo Immunodiagnost Lab, Sapporo, Hokkaido, Japan
来源：
OPHTHALMOLOGICA | 2001年 / 215卷 / 06期
关键词：
monocyte chemotactic protein-1; proliferative diabetic retinopathy; vitreous; proliferative membrane; retinal photocoagulation;
D O I：
10.1159/000050900
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To investigate the correlation between monocyte chemotactic protein-1 (MCP-1) levels in the vitreous and clinical findings in eyes with proliferative diabetic retinopathy (PDR). Methods: We assayed MCP-1 levels by ELISA in vitreous samples of 88 consecutive patients with PDR (52 eyes) and macular holes or idiopathic epimacular membrane (controls, 36 eyes). Results:The level of MCP-1 in the vitreous was 2,097.5 +/- 1,099.4 pg/ml (mean SD) in PDR, and 504.3 +/- 405.6 pg/ml in the controls. In PDR eyes, multivariate regression analysis revealed a significant association between MCP-1 levels in the vitreous and the degree of proliferative membrane, and a significant negative association between MCP-1 levels and the extent of preoperative retinal photocoagulation. Conclusion: The results suggest that MCP-1 may play a role in the development of the proliferative phase of PDR. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码：415 / 418
页数：4
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