Circulating Anodic Antigen (CAA): A Highly Sensitive Diagnostic Biomarker to Detect Active Schistosoma Infections-Improvement and Use during SCORE

被引:73
作者
Corstjens, Paul L. A. M. [1 ]
de Dood, Claudia J. [1 ]
Knopp, Stefanie [2 ,3 ]
Clements, Michelle N. [4 ,5 ]
Ortu, Giuseppina [6 ]
Umulisa, Irenee [7 ,8 ]
Ruberanziza, Eugene [7 ]
Wittmann, Udo [4 ,9 ]
Kariuki, Thomas [10 ,11 ]
LoVerde, Philip [12 ]
Secor, William Evan [13 ]
Atkins, Lydia [14 ]
Kinung'hi, Safari [15 ]
Binder, Sue [16 ]
Campbell, Carl H., Jr. [16 ]
Colley, Daniel G. [16 ,17 ]
van Dam, Govert J. [18 ]
机构
[1] Leiden Univ, Med Ctr, Dept Cell & Chem Biol, POB 9600, NL-2300 RC Leiden, Netherlands
[2] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
[3] Univ Basel, Basel, Switzerland
[4] SCI Fdn, London, England
[5] UCL, MRC Clin Trials Unit, London, England
[6] Sante Publ France, Paris, France
[7] Minist Hlth, Rwanda Biomed Ctr, Neglected Trop Dis & Other Parasit Dis Unit, Malaria & Other Parasit Dis Div, Kigali, Rwanda
[8] African Leaders Malaria Alliance, Dar Es Salaam, Tanzania
[9] Consult AG Stat Serv, Zurich, Switzerland
[10] Natl Museums Kenya, Inst Primate Res, Nairobi, Kenya
[11] African Acad Sci, Alliance Accelerating Excellence Sci Afr, Nairobi, Kenya
[12] Univ Texas Hlth, Dept Biochem & Struct Biol, San Antonio, TX USA
[13] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA USA
[14] Minist Hlth & Wellness, Castries, St Lucia
[15] Mwanza Res Ctr, Natl Inst Med Res, Mwanza, Tanzania
[16] Univ Georgia, Ctr Trop & Emerging Global Dis, Schistosomiasis Consortium Operat Res & Evaluat, Athens, GA 30602 USA
[17] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA
[18] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands
关键词
LATERAL FLOW ASSAY; OPERATIONAL-RESEARCH; CATHODIC ANTIGEN; MANSONI; URINE; SERUM; INTERRUPTION; VALIDATION; CONSORTIUM; JAPONICUM;
D O I
10.4269/ajtmh.19-0819
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was funded in 2008 to conduct research that would support country schistosomiasis control programs. As schistosomiasis prevalence decreases in many places and elimination is increasingly within reach, a sensitive and specific test to detect infection with Schistosoma mansoni and Schistosoma haematobium has become a pressing need. After obtaining broad input, SCORE supported Leiden University Medical Center (LUMC) to modify the serum-based antigen assay for use with urine, simplify the assay, and improve its sensitivity. The urine assay eventually contributed to several of the larger SCORE studies. For example, in Zanzibar, we demonstrated that urine filtration, the standard parasite egg detection diagnostic test for S. haematobium, greatly underestimated prevalence in low-prevalence settings. In Burundi and Rwanda, the circulating anodic antigen (CAA) assay provided critical information about the limitations of the stool-based Kato-Katz parasite eggdetection assay for S. mansoni in low-prevalence settings. Other SCORE-supported CAA work demonstrated that frozen, banked urine specimens yielded similar results to fresh ones; pooling of specimens may be a useful, cost-effective approach for surveillance in some settings; and the assay can be performed in local laboratories equipped with adequate centrifuge capacity. These improvements in the assay continue to be of use to researchers around the world. However, additional work will be needed if widespread dissemination of the CAA assay is to occur, for example, by building capacity in places besides LUMC and commercialization of the assay. Here, we review the evolution of the CAA assay format during the SCORE period with emphasis on urine-based applications.
引用
收藏
页码:50 / 57
页数:8
相关论文
共 46 条
[1]   THE RELATIONSHIP BETWEEN WORM BURDEN AND LEVELS OF A CIRCULATING ANTIGEN (CAA) OF 5 SPECIES OF SCHISTOSOMA IN MICE [J].
AGNEW, A ;
FULFORD, AJC ;
DEJONGE, N ;
KRIJGER, FW ;
RODRIGUEZCHACON, M ;
GUTSMANN, V ;
DEELDER, AM .
PARASITOLOGY, 1995, 111 :67-76
[2]   Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco: a pilot study [J].
Balahbib, Abdelaali ;
Amarir, Fatima ;
Corstjens, Paul L. A. M. ;
de Dood, Claudia J. ;
van Dam, Govert J. ;
Hajli, Amina ;
Belhaddad, Meryem ;
El Mansouri, Bouchra ;
Sadak, Abderrahim ;
Rhajaoui, Mohamed ;
Adlaoui, El Bachir .
INFECTIOUS DISEASES OF POVERTY, 2017, 6
[3]   Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy [J].
Bustinduy, Amaya L. ;
Waterhouse, David ;
de Sousa-Figueiredo, Jose C. ;
Roberts, Stephen A. ;
Atuhaire, Aaron ;
Van Dam, Govert J. ;
Corstjens, Paul L. A. M. ;
Scott, Janet T. ;
Stanton, Michelle C. ;
Kabatereine, Narcis B. ;
Ward, Stephen ;
Hope, William W. ;
Stothard, J. Russell .
MBIO, 2016, 7 (04)
[4]   SCORE Operational Research on Moving toward Interruption of Schistosomiasis Transmission [J].
Campbell, Carl H., Jr. ;
Binder, Sue ;
King, Charles H. ;
Knopp, Stefanie ;
Rollinson, David ;
Person, Bobbie ;
Webster, Bonnie ;
Allan, Fiona ;
Utzinger, Jurg ;
Ame, Shaali M. ;
Ali, Said M. ;
Kabole, Fatma ;
N'Goran, Eliezer K. ;
Tediosi, Fabrizio ;
Salari, Paola ;
Ouattara, Mamadou ;
Diakite, Nana R. ;
Hattendorf, Jan ;
Andros, Tamara S. ;
Kittur, Nupur ;
Colley, Daniel G. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2020, 103 (01) :58-65
[5]   Latent class analysis to evaluate performance of point-of-care CCA for low-intensity Schistosoma mansoni infections in Burundi [J].
Clements, Michelle N. ;
Corstjens, Paul L. A. M. ;
Binder, Sue ;
Campbell, Carl H., Jr. ;
de Dood, Claudia J. ;
Fenwick, Alan ;
Harrison, Wendy ;
Kayugi, Donatien ;
King, Charles H. ;
Kornelis, Dieuwke ;
Ndayishimiye, Onesime ;
Ortu, Giuseppina ;
Lamine, Mariama Sani ;
Zivieri, Antonio ;
Colley, Daniel G. ;
van Dam, Govert J. .
PARASITES & VECTORS, 2018, 11
[6]   Schistosomiasis Consortium for Operational Research and Evaluation (SCORE): Its Foundations, Development, and Evolution [J].
Colley, Daniel G. ;
Jacobson, Julie A. ;
Binder, Sue .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2020, 103 (01) :5-13
[7]   Evaluation, Validation, and Recognition of the Point-of-Care Circulating Cathodic Antigen, Urine-Based Assay for Mapping Schistosoma mansoni Infections [J].
Colley, Daniel G. ;
King, Charles H. ;
Kittur, Nupur ;
Ramzy, Reda M. R. ;
Secor, William Evan ;
Fredericks-James, Merlene ;
Ortu, Giuseppina ;
Clements, Michelle N. ;
Ruberanziza, Eugene ;
Umulisa, Irenee ;
Wittmann, Udo ;
Campbell, Carl H., Jr. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2020, 103 (01) :42-49
[8]   Contributions of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) to Schistosomiasis Control and Elimination: Key Findings and Messages for Future Goals, Thresholds, and Operational Research [J].
Colley, Daniel G. ;
Fleming, Fiona M. ;
Matendechero, Sultani H. ;
Knopp, Stefanie ;
Rollinson, David ;
Utzinger, Jurg ;
Castleman, Jennifer D. ;
Kittur, Nupur ;
King, Charles H. ;
Campbell, Carl H., Jr. ;
Kabole, Fatma M. ;
Kinung'hi, Safari ;
Ramzy, Reda M. R. ;
Binder, Sue .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2020, 103 (01) :125-134
[9]  
Corstjens P. L. A. M., 2005, IEE Proceedings Nanobiotechnology, V152, P64, DOI 10.1049/ip-nbt:20045014
[10]   Up-converting phosphor technology-based lateral flow assay for detection of Schistosoma circulating anodic antigen in serum [J].
Corstjens, Paul L. A. M. ;
van Lieshout, Lisette ;
Zuiderwijk, Michel ;
Kornelis, Dieuwke ;
Tanke, Hans J. ;
Deelder, Andre M. ;
van Dam, Govert J. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (01) :171-176